6 Result(s)
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Article
**aodong Lyu
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Article
Open AccessOrganoid technology and applications in cancer research
During the past decade, the three-dimensional organoid technology has sprung up and become more and more popular among researchers. Organoids are the miniatures of in vivo tissues and organs, and faithfully re...
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Open AccessGenetic editing and interrogation with Cpf1 and caged truncated pre-tRNA-like crRNA in mammalian cells
Cpf1, an RNA-guided DNA endonuclease that belongs to a new class II CRISPR system, has recently been harnessed for genome editing. Herein, we report an RNase-resistant caged truncated pre-tRNA-like crRNA (catR...
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Open AccessIdentification of a novel nonsense mutation in SH2D1A in a patient with X-linked lymphoproliferative syndrome type 1: a case report
X-linked lymphoproliferative syndrome type 1 (XLP1) is an X-linked recessive genetic disorder with a strong resemblance to hemophagocytic lymphohistiocytosis (HLH). Causative mutations for XLP1 have been ident...
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Open AccessDetection of 22 common leukemic fusion genes using a single-step multiplex qRT-PCR-based assay
Fusion genes generated from chromosomal translocation play an important role in hematological malignancies. Detection of fusion genes currently employ use of either conventional RT-PCR methods or fluorescent i...
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Open AccessA novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia
BCR-ABL1 fusion proteins contain constitutively active tyrosine kinases that are potential candidates for targeted therapy with tyrosine kinase inhibitors such as imatinib in chronic m...
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Open AccessNon-small cell lung cancer with EML4-ALKtranslocation in Chinese male never-smokers is characterized with early-onset
The translocations of the anaplastic lymphoma kinase (ALK) gene with the echinoderm microtubule-associated protein-like 4 (EML4) gene on chromosome 2p have been identified in non-small-cell lung cancers (NSCLCs) ...
