30 Result(s)

Article

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl⁻ concentration

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope (E) protein, a core virulence structural component of coron...

Jian-Bang Xu, Wei-Jie Guan, Yi-Lin Zhang… in Signal Transduction and Targeted Therapy (2024)

Article

Efficacy of Multifocal Soft Contact Lenses in Reducing Myopia Progression Among Taiwanese Schoolchildren: A Randomized Paired-Eye Clinical Trial

To evaluate the efficacy and safety of myopia control using a multifocal soft contact lens designed with high peripheral add power in schoolchildren.

Yao-Lin Liu, Ken-Kuo Lin, Li-Sheng Cheng, Chao-Wen Lin… in Ophthalmology and Therapy (2024)

Article

Exploring the potential use of Chinese herbs in regulating the inflammatory microenvironment of tumours based on the concept of ‘state-target identification and treatment’: a scoo** review

Tumours do not exist in isolation from the organism; their growth, proliferation, motility, and immunosuppressive response are intricately connected to the tumour’s microenvironment. As tumour cells and the mi...

**g Lian, Dongxin Lin, Yuchan Huang, **aohui Chen, Lian Chen… in Chinese Medicine (2023)

Article

Outcome and risk prediction of early progression in patients with extranodal natural killer/T cell lymphoma from the CLCG study

Recently, progression-free survival at 24 months (PFS24) was defined as clinically relevant for patients with extranodal NK/T cell lymphoma. Herein, the clinical data from two independent random cohorts (696 p...

Jia-Ying Li, **ao-Rong Hou, Si-Ye Chen, **n Liu, Qiu-Zi Zhong… in Annals of Hematology (2023)

Article

The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis

Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic eval...

Tong Wu, Rong Fan, Jian Bai, Zhao Yang, Yun-Song Qian… in Journal of Hematology & Oncology (2023)

Article

Mutational analysis of epidermolysis bullosa in Taiwan by whole-exome sequencing complemented by RNA sequencing: a series of 77 patients

Epidermolysis bullosa (EB) is a heterogeneous group of hereditary skin diseases characterized by skin fragility. Primary data on Taiwanese population remain scarce.

Wei-Ting Tu, **-Chen Hou, Peng-Chieh Chen… in Orphanet Journal of Rare Diseases (2022)

Article

SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl⁻ accumulation in respiratory epithelium

SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune responses and cytokine storms. Intracellular Cl⁻ is a crucial regulator of host defense, whereas the role of Cl⁻ signaling pathway in modulat...

Lei Chen, Wei-Jie Guan, Zhuo-Er Qiu… in Signal Transduction and Targeted Therapy (2022)

Article

Long-term outcomes of transanal endoscopic microsurgery for the treatment of rectal neuroendocrine tumors

Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess the efficacy and safety of TEM in the treatment of rectal neuroendocrine tumors...

Wei-Kun Shi, Rui Hou, Yun-Hao Li, **ao-Yuan Qiu, Yu-**n Liu, Bin Wu, Yi **ao… in BMC Surgery (2022)

Article

Six-month follow-up of functional status in discharged patients with coronavirus disease 2019

The long-term functional outcome of discharged patients with coronavirus disease 2019 (COVID-19) remains unresolved. We aimed to describe a 6-month follow-up of functional status of COVID-19 survivors.

Hou-wei Du, Shuang-fang Fang, Sang-ru Wu, **ao-ling Chen… in BMC Infectious Diseases (2021)

Article

A de novo variant of POLR3B causes demyelinating Charcot-Marie-Tooth disease in a Chinese patient: a case report

Charcot-Marie-Tooth (CMT) disease is a group of inherited peripheral neuropathies, which are subdivided into demyelinating and axonal forms. Biallelic mutations in POLR3B are the well-established cause of hypomye...

Yan-Yan Xue, Hao-Ling Cheng, Hai-Lin Dong, Hou-Min Yin, Yun Yuan… in BMC Neurology (2021)

Article

Correction to: Progression-free survival at 24 months and subsequent survival of patients with extranodal NK/T-cell lymphoma: a China Lymphoma Collaborative Group (CLCG) study

Yong Yang, Ying Wang, **n Liu, **a He, Li-Ling Zhang, Gang Wu, Bao-Lin Qu… in Leukemia (2021)

Article

Progression-free survival at 24 months and subsequent survival of patients with extranodal NK/T-cell lymphoma: a China Lymphoma Collaborative Group (CLCG) study

Limited evidence supports the use of early endpoints to evaluate the success of initial treatment of extranodal NK/T-cell lymphoma (ENKTCL) in the modern era. We aim to analyze progression-free survival at 24 ...

Yong Yang, Ying Wang, **n Liu, **a He, Li-Ling Zhang, Gang Wu, Bao-Lin Qu… in Leukemia (2021)

Article

Declined expressing mRNA of beta-defensin 108 from epididymis is associated with decreased sperm motility in blue fox (Vulpes lagopus)

Fecundity is important for farm blue fox (Vulpes lagopus), who with asthenospermia have be a problem in some of farms in China. A key symptom of asthenospermia is decreased sperm motility. The decreased secreting...

** Wu, Tao-lin Liu, Ling-ling Li, Zhi-** Liu, Li-hong Tian… in BMC Veterinary Research (2021)

Article

Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostl...

Si-Ye Chen, Yong Yang, Shu-Nan Qi, Ying Wang, Chen Hu, **a He, Li-Ling Zhang… in Leukemia (2021)

Article

Effects of different reminder strategies on first-time mammography screening among women in Taiwan

The study’s purpose was to examine the effectiveness of different reminder strategies on first-time free mammography screening among middle-aged women in Taiwan.

Miao-Ling Lin, Joh-Jong Huang, Shu-Hua Li, Fang-Hsin Lee… in BMC Health Services Research (2020)

Article

Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway

The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecul...

Jer-Wei Chang, Wen-Hung Kuo, Chiao-Mei Lin, Wen-Ling Chen, Shih-Hsuan Chan… in Oncogene (2018)