558 Result(s)

Article

Studies on the sites expressing evolutionary changes in the structure of eukaryotic 5S ribosomal RNA

We have determined the complete sequences of 5S rRNAs from a lamprey (Lampetra reissneri), a lancelet (Branchiostoma belcheri), silkworms (Philosamia cynthia ricini, Bombyx mori, Antheraea pernyi), and a silkworm...

Guo-rong Qi, Gong-jie Cao, Peng Jiang, **ao-li Feng… in Journal of Molecular Evolution (1988)

Article

A differential geometric treatment of protein structure comparison

The technique of model-building a protein of known sequence but unknown tertiary structure from the structures of homologous proteins is probably so far the most reliable means of map** from primary to terti...

Ding Da-Fu, Qian Jiang, Feng Zu-Kang in Bulletin of Mathematical Biology (1994)

Article

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

To develop an in vivo model for studying the role of the p53 tumor suppressor in skin carcinogenesis, a murine p53^172H mutant (equivalent to human p53^175H) was expressed in the epidermis of transgenic mice, utili...

**ao-**g Wang, David A Greenhalgh, Aibo Jiang, Dacheng He, Ling Zhong… in Oncogene (1998)

Article

Contributory presentations/posters

N. Manoj, V. R. Srinivas, A. Surolia, M. Vijayan, K. Suguna… in Journal of Biosciences (1999)

Article

The early cellular pathology of Huntington’s disease

Huntington’s disease (HD) is an inherited neurodegenerative disorder that affects about one in 10,000 individuals in North America. The genetic defect responsible for the disease is an expansion of a CAG repea...

**ao-Jiang Li in Molecular Neurobiology (1999)

Article

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways. Here, we report the frequent activation of AKT2...

Zeng Qiang Yuan, Mei Sun, Richard I Feldman, Gen Wang, **ao-ling Ma, Chen Jiang… in Oncogene (2000)

Article

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

Abnormalities in cellular differentiation are frequent occurrences in human cancers. Treatment of human melanoma cells with recombinant fibroblast interferon (IFN-β) and the protein kinase C activator mezerein...

Eric Y Huang, Malavi T Madireddi, Rahul V Gopalkrishnan… in Oncogene (2001)

Article

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells

Triptolide, a major component in the extract of Chinese herbal plant Tripterygium wilfordii Hook f (TWHf), has potential anti-neoplastic effect. In the present study we investigated the potential therapeutic e...

**ao-Hua Jiang, Benjamin Chun-Yu Wong, Marie Chia-Mi Lin, Geng-Hui Zhu… in Oncogene (2001)

Article

Preliminary study of the behavioral effects of LBS-neuron implantation on seizure susceptibility following middle cerebral artery occlusion in the rat

Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal ...

Alison E. Willing, Samuel Saporta, Jiang Lixian, Melissa Milliken… in Neurotoxicity Research (2002)

Article

Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β₁-dependent pathway

Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancers. Recently, a similar protective effect has been demonstrated by the specific cyclo-oxygenase-2 (COX-2) inhibitors. Howe...

**ao-Hua Jiang, Shiu-Kum Lam, Marie CM Lin, Shi-Hu Jiang, Hsiang-Fu Kung… in Oncogene (2002)

Article

Effects of Methyl jasmonate with indole-3-acetic acid and 6-benzylaminopurine on the secondary metabolism of cultured Onosma paniculatum cells

Methyl jasmonate (MeJA) interacted significantly with both indole-3-acetic acid (IAA) and 6-benzylaminopurine (BA) to influence cell growth of cultured Onosma paniculatum cells. Cell growth decreased with increas...

Jian Ding, Shuai Shi, Bao-Hua Jiang… in In Vitro Cellular & Developmental Biology … (2004)

Article

Time Dependent Effects of 6-OHDA Lesions on Iron Level and Neuronal Loss in Rat Nigrostriatal System

The early changes in iron level and neuronal loss in rat nigrostriatal system were investigated using 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats. The results showed that: 1, 3, 5, 7, and 14 days of ...

Jun Wang, Hong Jiang, Jun-**a **e in Neurochemical Research (2004)

Article

Sensitization of multiple myeloma and B lymphoma lines to dexamethasone and γ-radiation-induced apoptosis by CD40 activation

We examined the effects of CD40 activation with dexamethasone (Dex) or ⁶⁰Co-γ-irradiation on the growth of malignant B cells in vitro, using the human multiple myeloma (MM) cell line, XG2, and the B lymphoma Daud...

Zhao-Hua Zhou, Z-H. Zhou, Q. Shi, Qin Shi, Jiang-Fang Wang, Yong- **g Chen… in Apoptosis (2005)

Article

Expression and localization of p80 interleukin-1 receptor protein in the rat spinal cord

The biological effects of interleukin (IL)-1 are mediated by two distinct receptors, the p80 or type I (IL-1RI) and p68 or type II (IL-1RII) receptors. Because IL-1RII has a short, 29-amino acid cytoplasmic do...

**ao-Fei Wang, Lan Yin, Jian-Guo Hu, Li-Dong Huang… in Journal of Molecular Neuroscience (2006)

Article

A novel method to monitor the expression of microRNAs

The microRNAs (miRNAs) are an extensive class of small noncoding RNAs (18–25 nucleotides) with important roles in the regulation of gene expression. Although a large number of miRNAs have been identified in a ...

Han-Jiang Fu, Jie Zhu, Ming Yang, Zhuo-Yuan Zhang, Yi Tie… in Molecular Biotechnology (2006)

Article

Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis

Nephrotoxicity is a major side effect of cisplatin, a widely used cancer therapy drug. Depending on its concentration, cisplatin induces necrosis or apoptosis of tubular cells in the kidneys, whereas the under...

M Jiang, Q Wei, J Wang, Q Du, J Yu, L Zhang, Z Dong in Oncogene (2006)

Article

Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study

Mesenchymal stem cells (MSCs) are potential sources of cells for tissue repair. However, little information is available about the time course of homing and differentiation of systemically delivered MSCs after...

Wenhui Jiang, Aiqun Ma, Tingzhong Wang, Ke Han, Yu Liu, Yanmin Zhang… in Pflügers Archiv (2006)

Article

AICAR inhibits the Na⁺/H⁺ exchanger in rat hearts—possible contribution to cardioprotection

AICAR (5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide) is an adenosine analog which improves the recovery of the heart after ischemia. In some tissues AICAR enters cells and stimulates AMP-activated protein ...

Terence R. Moopanar, **ao-Hui **ao, Lele Jiang, Zhi-** Chen… in Pflügers Archiv (2006)

Article

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

The release of amyloid precursor protein (APP) intracellular domain (AICD) may be triggered by extracellular cues through γ-secretase-dependent cleavage. AICD binds to Fe65, which may have a role in AICD-depen...

Quan-Hong Ma, Toshitaka Futagawa, Wu-Lin Yang, **ao-Dan Jiang… in Nature Cell Biology (2008)

Article

Comparative Proteomics Analysis of Cerebrospinal Fluid of Patients with Guillain–Barré Syndrome

To better understand the pathophysiologic mechanisms underlying Guillain–Barré syndrome (GBS), Comparative proteomic analysis of cerebrospinal fluid (CSF) between patients with GBS (the experiment group) and c...

Yin-Rong Yang, Shi-Lian Liu, Zhao-Yu Qin, Fu-Jun Liu… in Cellular and Molecular Neurobiology (2008)