61 Result(s)

Article

The m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway

Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and dev...

Jun-Jun Chen, Tian-Zhu Lu, Tao Wang, Wen-Hui Yan, Fang-Yan Zhong… in Cell Death & Disease (2024)

Article

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Huntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact ...

Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, **gpan Lin… in Cell Death & Disease (2024)

Article

Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma

The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...

**n Li, Yu-Fei Pan, Yi-Bin Chen, Qian-Qian Wan, Yun-Kai Lin… in Cell Death & Disease (2024)

Article

The requirement of the mitochondrial protein NDUFS8 for angiogenesis

Mitochondria are important for the activation of endothelial cells and the process of angiogenesis. NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8) is a protein that plays a critical role in the functi...

Qian-wei **ong, Kun Jiang, **ao-wei Shen, Zhou-rui Ma… in Cell Death & Disease (2024)

Article

Correction: Clinical-mediated discovery of pyroptosis in CD8⁺ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Ying Zhang, Yun Bai, **ao-Xuan Ma, Jian-Kun Song, Yue Luo… in Cell Death & Disease (2024)

Article

The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process an...

Siyu Zhao, Yunyi Hu, Bicheng Yang, Lichao Zhang, Meiyining Xu… in Cell Death & Disease (2024)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons

Ischemic stroke is a neurological disorder caused by vascular stenosis or occlusion, accounting for approximately 87% of strokes. Clinically, the most effective therapy for ischemic stroke is vascular recanali...

Tao Li, Lili Zhao, Ye Li, Meijuan Dang, Jialiang Lu, Ziwei Lu… in Cell Death & Disease (2023)

Article

Clinical-mediated discovery of pyroptosis in CD8⁺ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence

Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in epidermal than in normal skin. Pyroptosis, a new frontier in can...

Ying Zhang, Yun Bai, **ao-Xuan Ma, Jian-Kun Song, Yue Luo… in Cell Death & Disease (2023)

Article

m5C-methylated lncRNA NR_033928 promotes gastric cancer proliferation by stabilizing GLS mRNA to promote glutamine metabolism reprogramming

Abnormal 5-methylcytosine (m5C) methylation has been proved to be closely related to gastric carcinogenesis, progression, and prognosis. Dysregulated long noncoding RNAs (lncRNAs) participate in a variety of b...

Lang Fang, Hongxin Huang, Jialun Lv, Zetian Chen, Chen Lu… in Cell Death & Disease (2023)

Article

SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1

Dysregulation of serine/arginine splicing factors (SRSFs) and abnormal alternative splicing (AS) have been widely implicated in various cancers but scarcely investigated in nasopharyngeal carcinoma (NPC). Here...

**ao-Chen Xu, Jia-**n Jiang, Ya-Qing Zhou, Shuai He, Yang Liu… in Cell Death & Disease (2023)

Article

CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway

Hypoxia contributes to the initiation and progression of glioblastoma by regulating a cohort of genes called hypoxia-regulated genes (HRGs) which form a complex molecular interacting network (HRG-MINW). Transc...

**ng-gang Mao, **ao-yan Xue, Rui Lv, Ang Ji, Ting-yu Shi… in Cell Death & Disease (2023)

Article

RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination

RNF2 is a RING domain-containing E3 ubiquitin ligase that mediate histone H2A mono-ubiquitination to repress gene transcription, but its expression patterns and molecular function in hepatocellular carcinoma (...

Lei Yao, Jun Li, Bo Jiang, Zeyu Zhang, **nying Li, **wu Ouyang… in Cell Death & Disease (2023)

Article

p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression

The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes en...

Jianhong Zhao, **aojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang… in Cell Death & Disease (2023)

Article

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products

Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleoti...

Wei Li, Wang-Sheng Jiang, Ya-Ru Su, Ke-Wu Tu, Lin Zou… in Cell Death & Disease (2023)

Article

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

In the widely used Carbon tetrachloride (CCl₄)-induced acute liver injury (ALI) mouse model, hepatocytes are known to die from programmed cell death (PCD) processes including apoptosis and necroptosis. Both in vi...

Ke Lu, Si-Yu Shen, Ou-Yang Luo, Yue Lu, Tian-Shu Shi, **g Wu… in Cell Death & Disease (2022)

Article

Correction: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...

Min Huang, Fang He, Dan Li, Ya-Jia **e, Ze-Bo Jiang, Ju-Min Huang… in Cell Death & Disease (2022)

Article

Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development

Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...

Wan-jun Yang, Rong-chang Cao, Wang **ao, **ao-lou Zhang, Hao Xu… in Cell Death & Disease (2022)

Article

CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair

Impaired energy metabolism in proximal tubular epithelial cells (PTECs) is strongly associated with various kidney diseases. Here, we characterized proximal tubular phenotype alternations during kidney injury ...

Qi Yuan, Yunhui Lv, Hao Ding, Qingqing Ke, Caifeng Shi, **g Luo… in Cell Death & Disease (2021)