Skip to main content

7 Result(s)

within English Remove this filter Internal Medicine Remove this filter Medical Microbiology Remove this filter Pharmacology/Toxicology Remove this filter **ang-Mei Ye Remove this filter Article Remove this filter

and

  1. No Access

    Article

    A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis

    Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the epidermal growth factor precursor homologous domain A (EGF-A) of low-density lipoprotein receptor (LDLR) in the liver and triggers the degrada...

    Wei-zhi Wang, Chao Liu, **-que Luo, Li-juan Lei… in Acta Pharmacologica Sinica (2024)

  2. No Access

    Article

    Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol

    Endothelial senescence, aging-related inflammation, and mitochondrial dysfunction are prominent features of vascular aging and contribute to the development of aging-associated vascular disease. Accumulating e...

    Zhi-hua Zheng, Jiao-jiao Wang, Jiu-guo Lin, Wei-le Ye… in Acta Pharmacologica Sinica (2024)

  3. No Access

    Article

    Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis

    Interleukin-1β (IL-1β), a key pro-inflammatory cytokine, is majorly produced by macrophages through NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome, which has been identified as the culp...

    Cheng Chen, Yong-mei Ren, Jian-zhong Zhu, Jia-li Chen… in Acta Pharmacologica Sinica (2022)

  4. No Access

    Article

    New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism

    Hypidone hydrochloride (YL-0919) is a novel antidepressant in clinical phase II trial. Previous studies show that YL-0919 is a selective 5-HT (serotonin) reuptake inhibitor, 5-HT1A receptor partial agonist, and 5...

    Yong-mei Zhang, Lu-yu Ye, Tian-yu Li, Fan Guo, Fei Guo… in Acta Pharmacologica Sinica (2022)

  5. No Access

    Article

    MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells

    Although the treatment of adult T-cell acute lymphoblastic leukemia (T-ALL) has been significantly improved, the heterogeneous genetic landscape of the disease often causes relapse. Aberrant activation of mamm...

    **an-bo Huang, Chun-mei Yang, Qing-mei Han, **u-** Ye… in Acta Pharmacologica Sinica (2018)

  6. Article

    LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1

    Glomerular endothelial cell (GEC) injury plays an important role in the early stage of diabetic nephropathy (DN). Previous studies show that a PKCβ inhibitor is effective for treating DN. In the current study ...

    Zhi-bin Wang, Su Zhang, Ya Li, Rong-mei Wang, Ling-chang Tong… in Acta Pharmacologica Sinica (2017)

    Download PDF (10474 KB) View Article

  7. Article

    Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury

    Interleukin-1 beta (IL-β) has been implicated as an extracellular signal in the initiation of apoptosis in neurons and oligodendrocytes after spinal cord injury (SCI). To further characterize the apoptotic cas...

    **n-jia Wang, Kang-mei Kong, Wei-li Qi, Wei-lian Ye… in Acta Pharmacologica Sinica (2005)

    Download PDF (1733 KB)