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110 Result(s)
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Article
Open AccessImpact of LDLR polymorphisms on lipid levels and atorvastatin’s efficacy in a northern Chinese adult Han cohort with dyslipidemia
Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein receptor (LDLR) gene. This stu...
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Open AccessTargeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2
Soft-tissue sarcomas (STS) emerges as formidable challenges in clinics due to the complex genetic heterogeneity, high rates of local recurrence and metastasis. Exploring specific targets and biomarkers would b...
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Open AccessUric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation
Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated the senescence of lens epithelial cells (LECs), leading to catarac...
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Open AccessMOCAT: multi-omics integration with auxiliary classifiers enhanced autoencoder
Integrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and heterogeneous datas...
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Correction to: Mediative Mechanism of Freezing/Thawing on Greenhouse Gas Emissions in an Inland Saline Alkaline Wetland: a Metagenomic Analysis
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Pathogenicity characteristics of the entomopathogenic fungus Cordyceps javanica IJ-tg19 to Acyrthosiphon pisum
Cordyceps javanica (Frieder. & Bally) (Hypocreales: Cordycipitaceae) is an important entomopathogenic fungus that is used as a mycoinsecticide to control pests such as aphids and whiteflies. However, few studies ...
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Mediative Mechanism of Freezing/Thawing on Greenhouse Gas Emissions in an Inland Saline-Alkaline Wetland: a Metagenomic Analysis
Inland saline-alkaline wetlands distributed in the mid-high latitude have repeatedly experienced freezing and thawing. However, the response of greenhouse gas (GHG) emission and microbially-mediated carbon and...
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LncRNA GNAS-AS1 knockdown inhibits keloid cells growth by mediating the miR-188-5p/RUNX2 axis
Keloid is a common dermis tumor, occurring repeatedly, affecting the quality of patients’ life. Long non-coding RNAs (lncRNAs) have crucial regulatory capacities in skin scarring formation and subsequent scar ...
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MdARF8: An Auxin Response Factor Involved in Jasmonate Signaling Pathway in Malus domestica
Auxin response factor (ARF) is a key component of auxin signal. The study of MdARF8 gene in apple shows that it is involved in the process of jasmonate regulating plant growth and development. Methyl jasmonate...
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Open AccessCOVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...
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Open AccessLoss of LXN promotes macrophage M2 polarization and PD-L2 expression contributing cancer immune-escape in mice
Latexin (LXN) plays an important role in tumorigenesis and inflammatory response and as a tumor suppressor in many tumors. However, whether LXN regulates tumorigenesis through immune regulation remains uncerta...
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Open AccessRole of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress
The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.
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Open AccessExosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway
Diabetic foot ulcer (DFU) is a chronic infectious disease caused by diabetes mellitus (DM). Angiogenesis plays the decisive role in wound healing of DFU. Adipose-derived stem cells (ADSCs) can ameliorate angio...
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Open AccessLatexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet
Obesity is a risk factor for many chronic diseases, and is associated with increased incidence rate of type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases. Adipocyte differentiation play cr...
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Open AccessComplete genome sequence of the kiwifruit bacterial canker pathogen Pseudomonas savastanoi strain MHT1
Pseudomonas savastanoi is an important plant pathogen that infects and causes symptoms in a variety of economically important crops, causing considerable loss of yield and quality. Because there has been no rese...
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A Spatial Ecological Study on Hair Selenium Level of Residents in Keshan Disease Endemic and Non-endemic Areas in Heilongjiang Province, China
This study was aimed to provide, by map** the spatial distribution of hair selenium levels of residents, visualized evidence for assessment of KD elimination from a perspective of selenium nutrition of the r...
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A Spatial Ecological Study on Serum Selenium and Keshan Disease in Heilongjiang Province, China
There are no reports on the spatial ecology of serum selenium and Keshan disease in Heilongjiang Province in China.
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Open AccessGenome-wide variant-based study of genetic effects with the largest neuroanatomic coverage
Brain image genetics provides enormous opportunities for examining the effects of genetic variations on the brain. Many studies have shown that the structure, function, and abnormality (e.g., those related to ...
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Genome surveying reveals the complete chloroplast genome and nuclear genomic features of the crocin-producing plant Gardenia jasminoides Ellis
Gardenia jasminoides, a well-known traditional Chinese herb, has been extensively utilized for its being as stable pigment in food industry and as rich source of crocin in treatment of various cancers and cardiov...
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Open AccessMultivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer’s disease
Genome-wide association studies (GWAS) have identified many individual genes associated with brain imaging quantitative traits (QTs) in Alzheimer’s disease (AD). However single marker level association discove...