25 Result(s)

Article

Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model

The present study was conducted to investigate whether alpha-lipoic acid (α-LA) is able to reverse impaired bladder function induced by diabetes in a rat model and to explore the possible mechanism mediating t...

Yuan-jun Jiang, Da-xin Gong, Hai-bo Liu, Chun-ming Yang… in Acta Pharmacologica Sinica (2008)

Article

Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives

Nicotinamide and catecholamines are both degraded by S-adenosylmethionine-dependent methylation. Whether excess nicotinamide affects the degradation of catecholamines is unknown. The aim of this study was to inve...

Wu-** Sun, Da Li, Yong-Zhi Lun, **ao-Jie Gong, Shen-**a Sun… in Hypertension Research (2012)

Article

The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report

Primary hepatic actinomycosis is a rare disease, but is important in the differential diagnosis of hepatoma in endemic areas. As high mobility group box chromosomal protein 1 plays an important role in the pat...

Chuan-**n Wu, Hui Guo, Jian-** Gong, Qi Liu, Hang Sun in Journal of Medical Case Reports (2013)

Article

Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice

Monocrotaline (MCT) in plants of the genus Crotalaria induces significant toxicity in multiple organs including the liver, lung and kidney. Metabolic activation of MCT is required for MCT-induced toxicity. In thi...

Jun Yao, Cheng-gang Li, Li-kun Gong, Chen-chen Feng… in Acta Pharmacologica Sinica (2014)

Article

Restoration of autophagic flux in myocardial tissues is required for cardioprotection of sevoflurane postconditioning in rats

Sevoflurane postconditioning (SpostC) has been shown to protect the heart from ischemia-reperfusion (I/R) injury. In this study, we examined whether SpostC affected autophagic flux in myocardial tissues that c...

Yu-lin Zhang, Yun-tai Yao, Neng-xin Fang, Cheng-hui Zhou… in Acta Pharmacologica Sinica (2014)

Article

Ezetimibe suppresses cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling

To investigate the mechanisms of anti-atherosclerotic action of ezetimibe in rat vascular smooth muscle cells (VSMCs) in vitro.

Li Qin, Yun-bo Yang, Yi-xin Yang, Neng Zhu, Yong-zhen Gong… in Acta Pharmacologica Sinica (2014)

Article

Congo red modulates ACh-induced Ca²⁺ oscillations in single pancreatic acinar cells of mice

Congo red, a secondary diazo dye, is usually used as an indicator for the presence of amyloid fibrils. Recent studies show that congo red exerts neuroprotective effects in a variety of models of neurodegenerat...

Ze-bing Huang, Hai-yan Wang, Na-na Sun, **g-ke Wang… in Acta Pharmacologica Sinica (2014)

Article

Strain/strain rate imaging of impaired left atrial function in patients with metabolic syndrome

Left ventricular (LV) dysfunction has been demonstrated in patients with metabolic syndrome (MetS). However, alterations in left atrial (LA) function in MetS are unknown. We aimed to use strain/strain rate (SR...

Ning-ning Fang, Dong-xin Sui, **-gui Yu, Hui-** Gong… in Hypertension Research (2015)

Article

Association between well-characterized lung cancer lncRNA polymorphisms and platinum-based chemotherapy toxicity in Chinese patients with lung cancer

Platinum-based chemotherapy is the standard first-line treatment for most lung cancer patients. However, the toxicity induced by platinum-based chemotherapy greatly impedes its clinical use. Previous studies s...

Wei-**g Gong, **g-bo Peng, Ji-ye Yin, ** Li… in Acta Pharmacologica Sinica (2017)

Article

The values of applying classification and counts of white blood cells to the prognostic evaluation of resectable gastric cancers

The classifications and counts of white blood cells (WBCs) have been proved to be able to be used as prognostic markers in cancer cases. The present study investigated the potential values of the classificatio...

Yin-Ling Wang, **n-**n Ge, Yi Wang, Meng-Dan Xu, Fei-Ran Gong… in BMC Gastroenterology (2018)

Article

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the vari...

Ying-Nan Wang, Yun-**n Lu, Jie Liu, Ying **, Hui-Chang Bi, Qi Zhao… in Oncogene (2020)

Article

Final adult height of children with idiopathic short stature: a multicenter study on GH therapy alone started during peri-puberty

To evaluate the efficacy of GH in improving FAH in ISS children in a multicenter study.

Di Wu, Rui-min Chen, Shao-ke Chen, Ge-li Liu, Lin-qi Chen, Yu Yang… in BMC Pediatrics (2020)

Article

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS

Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidi...

Zhuo Luo, Li-Fang Liu, Ying-Nan Jiang… in Signal Transduction and Targeted Therapy (2020)

Article

Early Diagnostic Biomarkers of Sepsis for Patients with Acute-on-Chronic Liver Failure: A Multicenter Study

Sepsis is a complication in acute-on-chronic liver failure (ACLF) patients associated with high rates of mortality and morbidity. Early diagnosis of sepsis in ACLF patients can improve prognosis. This study ai...

Jun Chen, Ze-Bing Huang, Hai Li, **n Zheng, **-Jun Chen… in Infectious Diseases and Therapy (2021)

Article

Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE)

While great attention has been paid to motor and cognitive impairments in children with neonatal Hypoxic-Ischemic Encephalopathy (HIE), sleep related circadian rhythm problems, although commonly present, are o...

Qiuyan Tian, Yizhi Pan, Zheng Zhang, Mei Li, Li-xiao Xu, Min Gong… in BMC Pediatrics (2021)

Article

Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis

Inhibition of autophagy has been accepted as a promising therapeutic strategy in cancer, but its clinical application is hindered by lack of effective and specific autophagy inhibitors. We previously identifie...

Li-wen Shen, **u-xing Jiang, Zhi-qiang Li, Jie Li, Mei Wang… in Acta Pharmacologica Sinica (2022)

Article

Human brucellosis and fever of unknown origin

Human brucellosis has become one of the major public health problems in China, and increases atypical manifestations, such as fever of unknown origin (FUO), and misdiagnosis rates has complicated the diagnosis...

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2022)

Article

Correction: Human brucellosis and fever of unknown origin

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a major challenge for clinicians and patients with non-small cell lung cancer (NSCLC). Serine-arginine protein kinase ...

**g-Qiang Huang, Ling-**n Duan, Qiu-Yu Liu, He-Feng Li, Ao-** Hu… in Oncogene (2023)