42 Result(s)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screeni...

Yue Zhou, Lei Tao, Jiahao Qiu, **g Xu… in Signal Transduction and Targeted Therapy (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (Cli...

Huaqing Wang, Jifeng Feng, Yanyan Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in ...

You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu… in Signal Transduction and Targeted Therapy (2023)

Article

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement...

**a Xu, Tao Yu, Lingling Dong, Rainer Glauben… in Signal Transduction and Targeted Therapy (2023)

Article

CXXC finger protein 1 (CFP1) bridges the resha** of genomic H3K4me3 signature to the advancement of lung adenocarcinoma

Histone H3 lysine 4 trimethylation (H3K4me3) is a canonical chromatin modification associated with active gene transcription, playing a pivotal role in regulating various cellular functions. Components of the ...

Tao Fan, Chu **ao, Hengchang Liu, Yu Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...

Shun Lu, Hongming Pan, Lin Wu, Yu Yao… in Signal Transduction and Targeted Therapy (2023)

Article

CRISPR/Cas9 therapeutics: progress and prospects

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting del...

Tianxiang Li, Yanyan Yang, Hongzhao Qi… in Signal Transduction and Targeted Therapy (2023)

Article

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial

An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...

Nawal Al Kaabi, Yun Kai Yang, Yu Liang, Ke Xu… in Signal Transduction and Targeted Therapy (2023)

Article

Lactate metabolism in human health and disease

The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis sugges...

**aolu Li, Yanyan Yang, Bei Zhang, **aotong Lin… in Signal Transduction and Targeted Therapy (2022)

Article

Engineered virus-like particles: paving the way for effective somatic genome editing

Chenya Zhuo, Yu Tao, Mingqiang Li in Signal Transduction and Targeted Therapy (2022)

Article

Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses

A steep rise in Omicron reinfection cases suggests that this variant has increased immune evasion ability. To evaluate its antigenicity relationship with other variants, antisera from guinea pigs immunized wit...

Qianqian Li, Li Zhang, Ziteng Liang, Nan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Natural killer cell homing and trafficking in tissues and tumors: from biology to application

Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense against cancer. Although some evidence shows that NK cells can develop in secondary lymphoid tissues, NK cells d...

Guang he Ran, Yu qing Lin, Lei Tian, Tao Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV: a phase 2 trial

The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess the immunogenicity and ...

Nawal Al Kaabi, Yun Kai Yang, **g Zhang, Ke Xu… in Signal Transduction and Targeted Therapy (2022)

Article

AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration

The cochlea consists of multiple types of cells, including hair cells, supporting cells and spiral ganglion neurons, and is responsible for converting mechanical forces into electric signals that enable hearin...

Yong Tao, **aoyi Liu, Liu Yang, Cenfeng Chu… in Signal Transduction and Targeted Therapy (2022)

Article

WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

Large scale genomic aberrations including duplication, deletion, translocation, and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of ca...

Rui Tao, Yanhong Wang, Yun Hu, Yaoge Jiao… in Signal Transduction and Targeted Therapy (2022)

Article

Nuclear Aurora kinase A switches m⁶A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical a...

SiSi Li, YangFan Qi, JiaChuan Yu, YuChao Hao… in Signal Transduction and Targeted Therapy (2022)