23 Result(s)
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Article
Open AccessPost-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment
Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-t...
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Article
Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke
Patients with severe stroke are at high risk of develo** acute respiratory distress syndrome (ARDS), but this severe complication was often under-diagnosed and rarely explored in stroke patients. We aimed to...
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Article
Characterization of posterior circulation blood perfusion in patients with different degrees of basilar artery tortuosity
The morphology of basilar artery (BA) may affect posterior circulation blood perfusion. We aimed to investigate whether different degrees of BA tortuosity could lead to the alterations of posterior circulation...
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Article
A visualized MAC nomogram online predicts the risk of three-month mortality in Chinese elderly aneurysmal subarachnoid hemorrhage patients undergoing endovascular coiling
Aneurysmal subarachnoid hemorrhage (aSAH) is an aggressive disease with higher mortality rate in the elderly population. Unfortunately, the previous models for predicting clinical prognosis are still not accur...
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Article
Han family with essential tremor caused by the P421L variant of the TENM4 gene in China
Essential tremor (ET) is an autosomal dominant inheritance disorder. Mutations in fusion sarcoma (FUS), mitochondrial serine peptidase 2 (HTRA2), teneurin transmembrane protein 4 (TENM4), sortilin1 (SORT1), SCN11...
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Metformin treatment and acute ischemic stroke outcomes in patients with type 2 diabetes: a retrospective cohort study
Preclinical studies have shown that metformin has neuroprotective actions in stroke. However, the optimal treatment timing and duration remain unknown. Herein, we examined the efficacy of metformin treatment o...
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Article
Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review
It has been assumed that patients with strict immunosuppressive treatment after solid organ transplantation have only marginal risk in develo** autoimmune encephalitis. We reported a woman in her late 40 s w...
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Article
Typical and atypical phenotype and neuroimaging of X-linked adrenoleukodystrophy in a Chinese cohort
The objective of this study is to describe the typical and atypical clinical and neuroimaging features of ALD in Chinese patients, which will help early diagnosis and intervention to improve prognosis of ALD.
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Article
Efficacy of azathioprine, mycophenolate mofetil, and rituximab in the treatment of neuromyelitis optica spectrum disorder and analysis of prognostic factors
The study aims to compare the efficacies of the immunosuppressants most commonly prescribed for patients with neuromyelitis optica spectrum disorder (NMOSD). The predictors, which might be associated with rela...
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Article
Leber hereditary optic neuropathy and dystonia overlap** mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes due to m.14459G>A mutation
To report a Chinese family with combined m.14459G>A mutation and m.6064A>T mutation of which the female proband presenting unique Leber hereditary optic neuropathy and dystonia (LDYT) overlap** mitochondrial...
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Article
Admission blood cell counts are predictive of stroke-associated infection in acute ischemic stroke patients treated with endovascular therapy
Stroke-associated infection (SAI) is a major medical complication in acute ischemic stroke patients (AIS) treated with endovascular therapy (EVT). Three hundred thirty-three consecutive patients with AIS cause...
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Article
Functional MRI in Parkinson’s disease with freezing of gait: a systematic review of the literature
Freezing of gait (FOG), a common and disabling symptom of Parkinson’s disease (PD), is characterized by an episodic inability to generate effective step**. Functional MRI (fMRI) has been used to evaluate abn...
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Article
Clinical significance of common-stem lenticulostriate arteries in patients with internal watershed infarction
A common-stem origin of lenticulostriate arteries (CS-LSAs) is an anatomical variation that supplies a moderate to large section of the basal ganglia. We hypothesized that CS-LSAs with a patent orifice are loc...
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Article
The predictive accuracy of the black hole sign and the spot sign for hematoma expansion in patients with spontaneous intracerebral hemorrhage
In patients with spontaneous intracerebral hemorrhage (sICH), hematoma expansion (HE) is associated with poor outcome. Spot sign and black hole sign are neuroimaging predictors for HE. This study was aimed to ...
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Article
The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects
The association between ALOX5AP SG13S114 polymorphism and ischemic stroke (IS) susceptibility has extensively been investigated, especially in white populations; however, the results were inconclusive. Here, w...
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Article
Genetic association study between RIT2 and Parkinson’s disease in a Han Chinese population
Recent several meta-analyses and certain case–control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson’s disease (PD) in Asian and Caucasian populations. Howeve...
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Article
Rapidly progressive neurological deterioration in anti-AMPA receptor encephalitis with additional CRMP5 antibodies
Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis positive for additional onconeural antibodies is rarely reported. Here we report the clinical features of a patient who d...
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Article
Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke
To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were ...
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Article
Identifying the role of microRNAs in spinal cord injury
Spinal cord injury (SCI) is medically and socioeconomically debilitating, and effective treatments are lacking. The elucidation of the pathophysiological mechanisms underlying SCI is essential for develo** e...
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Article
Connections between EM2- and SP-containing terminals and GABAergic neurons in the mouse spinal dorsal horn
Endomorphin-2 (EM2) demonstrates a potent antinociceptive effect in pain modulation. To investigate the potential interactions of EM2- and substance P (SP)-containing primary afferents and γ-amino butyric acid...
