83 Result(s)
within
Article
**-li Lu
Neurology
Neurosurgery
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Article
Open AccessPost-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment
Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-t...
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Open AccessMiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene
Hypoxia can cause a variety of diseases, including ischemic stroke and neurodegenerative diseases. Within a certain range of partial pressure of oxygen, cells can respond to changes in oxygen. Changes in oxyge...
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Prevalence, predictors, and outcomes of acute respiratory distress syndrome in severe stroke
Patients with severe stroke are at high risk of develo** acute respiratory distress syndrome (ARDS), but this severe complication was often under-diagnosed and rarely explored in stroke patients. We aimed to...
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Impact of obesity-related indicators on first-pass effect in patients with ischemic stroke receiving mechanical thrombectomy
The first-pass effect (FPE), defined as complete revascularization after a single thrombectomy pass in large vessel occlusion, is a predictor of good prognosis in patients with acute ischemic stroke (AIS) rece...
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Characterization of posterior circulation blood perfusion in patients with different degrees of basilar artery tortuosity
The morphology of basilar artery (BA) may affect posterior circulation blood perfusion. We aimed to investigate whether different degrees of BA tortuosity could lead to the alterations of posterior circulation...
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Open AccessMultiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)
Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiol...
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Tenecteplase Plus Butyphthalide for Stroke Within 4.5–6 Hours of Onset (EXIT-BT): a Phase 2 Study
To date, the benefit of intravenous thrombolysis is confined to within 4.5 h of onset for acute ischemic stroke (AIS) without advanced neuroimaging selection. The current trial aimed to investigate the safety ...
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Open AccessAnalysis of complement system and its related factors in Alzheimer’s disease
Alzheimer’s disease (AD) is a primary cause of dementia. The complement system is closely related to AD pathology and may be a potential target for the prevention and treatment of AD. In our study, we conducte...
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Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule
Ischemic-reperfusion injury limits the time window of recanalization therapy in cerebral acute ischemic stroke (AIS). Brain vessel endothelial cells (BVECs) form the first layer of the blood–brain barrier (BBB...
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Open AccessPatterns of use of symptomatic treatments for Alzheimer's disease dementia (AD)
Symptomatic treatment for Alzheimer's disease (AD) dementia could temporarily slow symptom worsening and improve the quality of life for both AD dementia patients and their caregivers. A comprehensive evaluati...
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White Blood Cell Count Predicts Mortality in Patients with Spontaneous Intracerebral Hemorrhage
The association between white blood cell (WBC) counts and mortality in patients with intracerebral hemorrhage (ICH) has not been established. The aim of this study is to determine whether higher WBC is associa...
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A visualized MAC nomogram online predicts the risk of three-month mortality in Chinese elderly aneurysmal subarachnoid hemorrhage patients undergoing endovascular coiling
Aneurysmal subarachnoid hemorrhage (aSAH) is an aggressive disease with higher mortality rate in the elderly population. Unfortunately, the previous models for predicting clinical prognosis are still not accur...
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Clinical Significance and Influencing Factors of Microvascular Tissue Reperfusion After Macrovascular Recanalization
The relevance of impaired microvascular tissue reperfusion despite successful macrovascular angiographic reperfusion (no-reflow) in acute ischemic stroke (AIS) remains controversial. In this study, we aimed to...
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Open AccessA Clinical Prediction Model for Patients with Acute Large Vessel Occlusion Due to Underlying Intracranial Atherosclerotic Stenosis
Acute large vessel occlusion due to underlying intracranial atherosclerotic stenosis (ICAS-LVO) increases the difficulty of revascularization, resulting in frequent re-occlusion. The establishment of its patho...
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Han family with essential tremor caused by the P421L variant of the TENM4 gene in China
Essential tremor (ET) is an autosomal dominant inheritance disorder. Mutations in fusion sarcoma (FUS), mitochondrial serine peptidase 2 (HTRA2), teneurin transmembrane protein 4 (TENM4), sortilin1 (SORT1), SCN11...
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Open AccessLymphomatoid granulomatosis with the central nervous system involvement as the main manifestation: a case report
Lymphomatoid granulomatosis (LyG) is a rare extralymphatic lymphoproliferative disease characterized by lymphocytic invasion into vascular walls and damage to blood vessels. The lungs are affected in 90% of Ly...
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Open AccessAnti-ganglioside antibody positive neuromyelitis optica spectrum disorders with peripheral neuropathy: a case report
Neuromyelitis optica spectrum disorders (NMOSD) is a group of autoimmune-mediated disorders of the central nervous system primarily involving the optic nerve and spinal cord. There are limited reports of NMOSD...
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Open AccessChinese expert consensus on the management of aneurysmal subarachnoid hemorrhage-related hydrocephalus
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Metformin treatment and acute ischemic stroke outcomes in patients with type 2 diabetes: a retrospective cohort study
Preclinical studies have shown that metformin has neuroprotective actions in stroke. However, the optimal treatment timing and duration remain unknown. Herein, we examined the efficacy of metformin treatment o...
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Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review
It has been assumed that patients with strict immunosuppressive treatment after solid organ transplantation have only marginal risk in develo** autoimmune encephalitis. We reported a woman in her late 40 s w...
