45 Result(s)
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Article
**-lei Niu
Life Sciences
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Article
Open AccessFast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei using Microwell-seq3
Single cell chromatin accessibility profiling and transcriptome sequencing are the most widely used technologies for single-cell genomics. Here, we present Microwell-seq3, a high-throughput and facile platform...
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Open AccessUnderstanding predictors of mistletoe infection across an urban university campus in Southwest China
Due to the importance of trees in urban ecosystems, it is crucial to understand the distribution, prevalence, and intensity of parasitic mistletoe infection across urban landscapes. In this study, we aimed to ...
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Open AccessLysobacter chang**ensis sp. nov., a novel species of the genus Lysobacter isolated from a rhizosphere soil of strawberry in China
In the present work, we characterized in detail strain CM-3-T8T, which was isolated from the rhizosphere soil of strawberries in Bei**g, China, in order to elucidate its taxonomic position. Cells of strain CM-3-...
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Open AccessA NAC transcription factor, PpNAC1, regulates the expression of PpMYB10.1 to promote anthocyanin biosynthesis in the leaves of peach trees in autumn
Red leaves in autumn are characteristic of a very early-maturing ripening variety of peach (Prunus persica). Analysis of the genetic factors and molecular mechanisms associated with the red-leaf phenotype can hel...
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Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions
Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...
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The Arabidopsis SPL9 Transcription Factor Regulates Phosphate Acquisition and miR399f Expression under Phosphate Deprivation
Transcription factors play an important role in the signaling of Pi deficit. We show that Arabidopsis SPL9 regulates the phosphate (Pi) deficit response. We report here that the SPL9 of Arabidopsis modulates the ...
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Open AccessTuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, th...
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Dynamic carbon-nitrogen coupling under global change
Carbon-nitrogen coupling is a fundamental principle in ecosystem ecology. However, how the coupling responds to global change has not yet been examined. Through a comprehensive and systematic literature review...
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Open AccessHOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer
Enabled resistance or innate insensitiveness to antiandrogen are lethal for castration-resistant prostate cancer (CRPC). Unfortunately, there seems to be little can be done to overcome the antiandrogen resista...
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Characterization and expression analysis of basic leucine zipper (bZIP) transcription factors responsive to chilling injury in peach fruit
Peach (Prunus persica L.) is prone to chilling injury as exhibited by inhibition of the ethylene production, failure in softening, and the manifestation of internal browning. The basic leucine zipper (bZIP) trans...
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5′-Nucleotidase is dispensable for the growth of Salmonella Typhimurium but inhibits the bactericidal activity of macrophage extracellular traps
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes severe gastroenteritis. The 5′-nucleotidases of pathogens can dephosphorylate adenosine phosphates, boost adenosine leve...
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Open AccessIntegration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs
The genetic mechanisms that underlie phenotypic differentiation in breeding animals have important implications in evolutionary biology and agriculture. However, the contribution of cis-regulatory variants to ...
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Validation of reliable safe harbor locus for efficient porcine transgenesis
Transgenic technology is now widely used in biomedical and agricultural fields. Transgenesis is commonly achieved through random integration which might cause some uncertain consequences. The site-specific int...
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Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury
Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI). Ferroptosis has been recently implicated in APAP-induced liver injury (AILI). However, the functional role and underlying me...
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Stenotrophomonas nematodicola sp. nov., isolated from Caenorhabditis elegans
A Gram stain-negative, coccoid rod-shaped, motile by gliding, facultatively aerobic bacterium, designated W5, was isolated from Caenorhabditis elegans samples in Baotianman Natural Reserve (33° 27′ 47′′ N; 111° 4...
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Enhanced SA and Ca2+ signaling results in PCD-mediated spontaneous leaf necrosis in wheat mutant wsl
Leaf is the major photosynthesis organ and the key source of wheat (Triticum aestivum L.) grain. Spotted leaf (spl) mutant is a kind of leaf lesion mimic mutants (LMMs) in plants, which is an ideal material for s...
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Open AccessLactobacillus plantarum surface-displayed ASFV (p54) with porcine IL-21 generally stimulates protective immune responses in mice
African classical swine fever virus (ASFV) has spread seriously around the world and has dealt with a heavy blow to the pig breeding industry due to the lack of vaccines. In this study, we produced recombinant La...
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CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells
CBX8 is the core component of the PCG family protein PRC1 complex. It is overexpressed in many solid tumors and plays an important role in the prognosis and biological behaviors of tumors such as occurrence, d...
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Discovery of a Novel Cysteine Framework XXIV Conotoxin from Conus striatus, S24a, with Potential Analgesic Activity
A novel conotoxin, S24a, containing 26 amino acid residues was first derived from the cDNA library of Conus striatus. This conotoxin has the same conserved signal peptide as A-superfamily conotoxins and some unco...
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Open AccessThe Tetracentron genome provides insight into the early evolution of eudicots and the formation of vessel elements
Tetracentron sinense is an endemic and endangered deciduous tree. It belongs to the Trochodendrales, one of four early diverging lineages of eudicots known for having vesselless secondary wood. Sequencing and res...
