66 Result(s)
within
Biomedicine
Immunology
Pharmacology/Toxicology
**** Chu
Article
-
Article
Baculovirus ETL promoter acts as a shuttle promoter between insect cells and mammalian cells
To identify a shuttle promoter that can mediate gene expression in both insect cells and mammalian cells to facilitate the development of a baculovirus vector-based mammalian cell gene delivery vehicle.
-
Article
Pranlukast reduces neutrophil but not macrophage/microglial accumulation in brain after focal cerebral ischemia in mice
To determine whether pranlukast, a cysteinyl leukotriene receptor-1 antagonist, exerts an anti-inflammatory effect on focal cerebral ischemia in mice.
-
Article
Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib
To investigate the in vitro metabolism of imrecoxib in rat liver microsomes and to identify the cytochrome P450 (CYP) forms involved in its metabolism.
-
Article
Formation of 4′-carboxyl acid metabolite of imrecoxib by rat liver microsomes
Imrecoxib is a novel and moderately selective COX-2 inhibitor. The aim of the present in vitro investigation was to study the formation of the major metabolite 4′-carboxylic acid imrecoxib (M2) and identify the e...
-
Article
Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats
To investigate the effects of caffeic acid on early and delayed injuries after focal cerebral ischemia in rats, and the possible relation to 5-lipoxygenase inhibition.
-
Article
Antisense oligonucleotide targeting p53 increased apoptosis of MCF-7 cells induced by ionizing radiation
To investigate the effect of antisense compounds (AS) targeting human p53 mRNA on radiosensitivity of MCF-7 cells.
-
Article
Influence of CYP3A5 genetic polymorphism on cyclosporine A metabolism and elimination in Chinese renal transplant recipients
To investigate whether the CYP3A5*3 polymorphism would affect cyclosporine A (CsA) metabolism in Chinese renal transplant patients.
-
Article
Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine
To investigate a new strategy to enhance the efficacy of a recombinant pertussis DNA vaccine. The strategy is co-injection with cytokine plasmids as prime, and boosted with purified homologous proteins.
-
Article
Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats
To investigate the possible synergism of hydrochlorothiazide and nitrendipine on reducing both blood pressure (BP) and blood pressure variability (BPV) in spontaneously hypertensive rats (SHR).
-
Article
Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata
To investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipop...
-
Article
l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons
To investigate the effect of l-stepholidine (SPD) on the frequency of spontaneous excitatory postsynaptic currents (sEPSC) in the pyramidal cells between layers V and VI in the prelimbic cortex (PL).
-
Article
Requirement of PSD-95 for dopamine D1 receptor modulating glutamate NR1a/NR2B receptor function
To elucidate the role of scaffold protein postsynaptic density (PSD)-95 in the dopamine D1 receptor (D1R)-modulated NR1a/NR2B receptor response.
-
Article
Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats
To determine whether the anti-inflammatory effect of minocycline on postischemic brain injury is mediated by the inhibition of 5-lipoxygenase (5-LOX) expression and enzymatic activation in rats.
-
Article
Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine
To examine whether (-)-stepholidine (SPD) has a direct effect on the N-methyl-D-aspartic acid receptors (NMDAR) containing the NMDA receptor subunits NR2A or NR2B and to compare its effect with those of halope...
-
Article
Polypeptide from Chlamys farreri attenuates murine thymocytes damage induced by ultraviolet B
Polypeptide from Chlamys farreri (PCF, molecular mass is 879) is a new marine polypeptide compound isolated from Chlamys farreri. This study investigates the possible protective roles and the mechanism of PCF aga...
-
Article
Proteomic analysis of HuH-7 cells harboring in vitro-transcribed full-length hepatitis C virus 1b RNA
The present study examined the differential expression of proteins in HuH-7 cells and HuH-7 cells harboring in vitro-transcribed full-length hepatitis C virus 1b RNA (HuH-7-HCV), and elucidated the cellular respo...
-
Article
Investigation of non-covalent complexes of glutathione with common amino acids by electrospray ionization mass spectrometry
To study the non-covalent interaction between glutathione and common amino acids.
-
Article
Amantadine as a regulator of internal ribosome entry site
Studies of eukaryotes have yielded 2 translation initiation mechanisms: a classical cap-dependent mechanism and a cap-independent mechanism proceeding through the internal ribosomal entry site (IRES). We hypot...
-
Article
Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX1
To determine whether the antitumor factor nm23 is related with antioxidation.
-
Article
Effects of allisartan, a new AT1 receptor blocker, on blood pressure and end-organ damage in hypertensive animals
To investigate the effects of allisartan, a new angiotensin II type 1 (AT1) receptor antagonist, on blood pressure (BP) and end-organ damage (EOD) in hypertensive rats and dogs.
