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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature mortality among people with epilepsy (PWE). The overall incidence rate of...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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Autonomic Cardiac Regulation in Response to Exercise and Molecular Hydrogen Administration in Well-Trained Athletes
Exercise induces considerable changes in the autonomic nervous system (ANS). The main objective of this chapter was to determine whether H2...
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Role of Matrix Metalloproteinases in Effects of Molecular Hydrogen
Molecular hydrogen plays a role in modulating several cellular functions and in several diseases were documented its pleiotropic therapeutic effects....
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Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis
Azithromycin was introduced in lung transplantation in an attempt to improve the pulmonary function in patients with chronic allograft dysfunction...
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Non-CF Bronchiectasis
Bronchiectasis is a disease of recurrent wet cough and acute respiratory exacerbations with objective confirmation by abnormal bronchial dilatation...
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Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity
In addition to the antiinflammatory/immunoregulatory actions of macrolide antibiotics, more recent investigations indicate the potential...
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Macrolides and Asthma Therapy
Asthma is a chronic condition of the airways that is typified by bronchial hyperresponsiveness, variable airflow obstruction, and airway...
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Macrolides and Cystic Fibrosis
Macrolide antibiotics attracted interest as a potential therapy in cystic fibrosis (CF) due to remarkable similarities in pathogenic features with...
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Principles of Tomographic Reconstruction
Imagine you need to look inside a living organism. You would have only two options: using invasive techniques or applying tomography. In this...
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Treatment of Erythrodermic Atopic Dermatitis with Cyclosporine
Cyclosporine is an immunosuppressive drug that inhibits calcineurin to suppress T-cell activation. Multiple studies have demonstrated that...
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AD and Psychodermatology/Quality of Life
Atopic dermatitis (AD) can have a profound impact on an individual’s physical, emotional, and social well-being. Patients with AD have a higher...
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Treatment of AD with Upadacitinib
Targeted Janus kinase (JAK) 1 inhibition suppresses cytokine signaling pathways involved in the pathogenesis of atopic dermatitis. Upadacitinib is...
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Treatment of Pediatric AD
Severe pediatric atopic dermatitis (AD) is often undertreated due to lack of access to appropriate specialty care and provider/caregiver concerns...
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Management of Facial Erythema on Dupilumab Treatment
Dupilumab is a biologic agent that inhibits IL-4 and IL-13 to treat atopic dermatitis. Though dupilumab has been found to be safe and effective in...
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Beam-Induced Motion Mechanism and Correction for Improved Cryo-Electron Microscopy and Cryo-Electron Tomography
Beam induced motion (BIM) is a major cause of information loss in single-particle cryo-electron microscopy (cryo-EM) and cryo-electron tomography...
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Electron Tomography of Cryo-Fixed and Resin-Embedded Samples
Room-temperature electron tomography of sections prepared from high-pressure frozen, freeze-substituted and resin-embedded cells is a powerful method...
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Treatment of AD with Topical Therapy
Atopic dermatitis (AD) has a complex pathogenesis that leads to the characteristic itchy, eczematous skin findings. Treatment of AD is aimed at...
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Introduction to Atopic Dermatitis (AD)
Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases with rising incidence. It usually presents in childhood and can...