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The Endoplasmic Reticulum: A Central Player in Cell Signalling and Protein Synthesis
In addition to being the principle intracellular Ca 2+ store, the endoplasmic reticulum (ER) is the initial site of synthesis and folding of membrane...
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Global and Local Regulation of Neuronal Differentiation by Calcium Transients
Embryonic spinal neurons express ion channels prior to synaptogenesis that mediate specialized forms of excitability promoting Ca 2+ influx. Ca 2+...
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Role of NAADP in Coordinating Spatiotemporal Aspects of Calcium Signalling
We outline the roles of two low molecular weight phosphorylated compounds as intracellular messengers in calcium signaling. These new intracellular...
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10 Sphingosine-1-phosphate metabolism in mammalian cell signalling
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
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8 Biosynthesis and compartmentation of triacylglycerol in higher plants
The biosynthesis of storage lipids (triacylglycerols) in higher plants is now known to occur via a number of different routes. These include the...
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Introduction: Lipids: cellular glue...or are they more than that?
Some 40 years ago, there was a rumor in the research community that lipids are the stuff you have to throw away before starting biochemical...
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Mitochondrial and ER Calcium Uptake and Release Fluxes and their Interplay in Intact Nerve Cells
Ionized free Ca ( Ca 2+) is a ubiquitous signaling ion that serves as the critical link between a variety of physiological stimuli and their...
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Building a Wave – Models of the Puff-to-Wave Transition
Ca2+ release channels open and close randomly because of random binding and dissociation of Ca2+ and IP3 to their subunits. They are arranged in...
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In Vitro Enzyme-Induced Vinyl Polymerization
The in vitro enzyme-mediated polymerization of vinyl monomers is reviewed with a scope covering enzymatic polymerization of vitamin C...
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Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy
The atomic force microscope (AFM) is capable of acquiring a range of structural and physicochemical information on a wide range of biopolymers. The...
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Enzymatic Catalysis in the Synthesis of Polyanilines and Derivatives of Polyanilines
Enzyme catalysis in the synthesis of polyaniline is reviewed. Oxidoreductase enzymes and biomimetic catalysts have been used for the polymerization...
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Polymer Genomics
Biological activities of biocompatible synthetic polymers used in drug delivery, gene delivery, vaccine development or biomaterial surface...
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Solid-State Structure, Organizationand Properties of Peptide—Synthetic Hybrid Block Copolymers
Peptide–synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides using...
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Detection of Mutations in Rifampin-Resistant Mycobacterium Tuberculosis by Short Oligonucleotide Ligation Assay on DNA Chips (SOLAC)
A new approach, a short oligonucleotide ligation assay on DNA chips (SOLAC) is developed to detect DNA mutations. The SOLAC approach can be carried...
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Domino Dendrimers
Domino dendrimers have recently been developed and introduced as a potential platform for a single triggered multi-prodrug. Surprisingly, three...
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Enzymatic Synthesis of Polyesters via Polycondensation
In vitro synthesis of polyesters by polycondensation using isolated enzymes as catalyst via nonbiosynthetic pathways is reviewed. In most cases,...
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Synthesis of Bio-Inspired Hybrid PolymersUsing Peptide Synthesis and Protein Engineering
The construction of well-defined hybrid materials consisting of synthetic polymers and (poly)peptides or proteins has attracted much attention in...
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Preparation and Electron Conductivity of DNA-Aligned Cast and LB Films from DNA-Lipid Complexes
We describe here a simple preparation of a DNA-lipid complex that is soluble in organic media, and preparations of DNA-aligned thin films from the...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...