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Medicinal Plants Against Neurological Viral Diseases: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
In the 6000 BC India, China, Africa, and Pre-Columbian America, especially the Aztecs and Incas, used herbal remedies for the treatment of...
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Poxvirus and the Role of Medicinal Plants in Controlling Infections: Ethnopharmacology, Chemistry, Clinical and Preclinical Studies, and Future Perspectives
Today, viral infections are causing an unexpectedly high incidence of mortality over the world. The enormous double-stranded DNA genomes of...
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Natural Medicinal Plants Used in the Control and Treatment of Diseases Caused by Coxsackie and Coxsackie Virus B3: Possible Mechanism of Action and the Role of Phytochemicals
Coxsackie viruses are viruses that cause a variety of devastating human disorders, including myocarditis and meningoencephalitis. Despite the fact...
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Traditional Crude Drugs Against Encephalitis Infection: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Encephalitis infection is an infection in the brain causing inflammation of the brain. An infection or an autoimmune response generally causes...
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Medicinal Plants in Controlling and Treatment of Cutaneous Viral Diseases: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Skin is the largest organ of our body, comprised of a few distinct parts, including water, proteins, lipids (fats), and various minerals. During our...
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Medicinal Plants Against Vesicular Stomatitis Virus (VSV) Infections: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Vesicular stomatitis virus (VSV) is a rhabdovirus, that is, an encapsulated negative-sense RNA virus. VSV could be spread from insects to mammals,...
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Natural Products in Controlling and Treatment of Cancers and Genital Warts Caused by Different Viruses
Cancer is a disease characterized by uncontrolled cell division and fast metastasis to various body parts. Cancer is the leading global threat...
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Fundamentals of Molecular Biotechnology
The genetic code of living organisms is universal, that is, the process of transformation (transcription/translation) of DNA into proteins is similar...
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Biologicals
Some drugs belong to both groups. For example, semi-synthetic antibiotics, whose molecules are first obtained by fermentation processes and then...
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Cell Therapy
The cell therapy involves the transfer of intact and living cells to a patient, with the aim of treating, alleviating or curing a disease. These...
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Nucleic Acid-Based Therapies
The genes interfere with almost all human diseases, either by inducing the expression of abnormal disease-causing proteins; or by determining...
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Construction of Quinoline N-Oxides and Synthesis of Aurachins A and B: Discovery, Application, and Mechanistic Insight
A method to synthesize 3-hydroxyquinoline N-oxides from ketones having a 2-nitrophenyl group at the α-position relative to the carbonyl group was...
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Utilizing the pKa Concept to Address Unfavorable Equilibrium Reactions in the Total Synthesis of Palau’amine
Herein, we introduce the pKa concept as a strategy for proceeding with unfavorable reactions in the total synthesis of palau’amine. The cascade...
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Total Synthesis of a Marine Bromotriterpenoid Isodehydrothyrsiferol
The thyrsiferol family natural products are marine triterpene polyethers biogenetically derived from squalene and structurally characterized by a...
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Synthetic Study of Bio-functional Glycans
The molecular structures responsible for the immune functions of complex glycans were unraveled by synthetic studies. We focused on develo**...
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A Long Journey Toward Structure Revision and Total Synthesis of Amphidinol 3
Amphidinol 3 (AM3) is a super-carbon-chain compound isolated from the dinoflagellate Amphidinium klebsii. Although the absolute configuration of AM3...
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Pursuing Step Economy in Total Synthesis of Complex Marine Macrolide Natural Products
Here I describe our first-, second-, and third-generation synthesis of (+)-neopeltolide, which is a Jamaican marine macrolide that shows potent...
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Unified Total Synthesis of Madangamine Alkaloids
Development of a unified total synthesis of madangamine alkaloids is described. The synthesis consists of three parts: (1) construction of the...
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Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids
The synthesis of alkaloids featuring fused polycyclic frameworks has long attracted the interest of synthetic organic communities, owing to their...
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General Concepts
The overall concept of Biotechnology defines it as the technology that uses living organisms or parts of them, for the production of goods and...