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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Educator Knowledge of Childhood Conduct Problems and Callous-Unemotional Traits
Research evaluating mental health literacy (MHL) of adults who support children with mental health difficulties is relatively scarce. To date, no...
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The effect of the exit of an insurer, due to government liquidation, on access to health care: evidence from Colombia
Our study evaluates the liquidation effect of a health insurer from a subsidized scheme, with the largest number of members in Colombia, on...
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Entering the Classroom: Do Newcomers Experience More Peer Victimization than Their Established Peers?
Students changing classrooms or schools may face challenges from entering a new peer context without friends and standing out from the crowd as newcomers...
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Consensus paper on the management of acute isolated vertigo in the emergency department
Acute vertigo is defined as the perception of movement of oneself or the surroundings in the absence of actual motion and it is a frequent cause for...
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
PurposeLong noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with...
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Novel Vpx virus-like particles to improve cytarabine treatment response against acute myeloid leukemia
Knowledge of the molecular pathogenesis of acute myeloid leukemia has advanced in recent years. Despite novel treatment options, acute myeloid...
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Contamination status, source analysis and exposure assessments of quinolone antibiotics in the south of Yancheng Coastal Wetland, China
Yancheng coastal wetland, the largest coastal wetland in the west coast of the Pacific Ocean and the margin of the Asian continent, has significant...
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Healthcare costs and medical utilization patterns associated with painful and severe painful diabetic peripheral neuropathy
PurposePainful diabetic peripheral neuropathy (DPN) is a common complication in patients with diabetes. It is associated with a poor quality of life...
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Holistic assessment of dimethoate toxicity in Carcinus aestuarii’s muscle tissues
Dimethoate (DMT) is one of the most harmful and commonly used organophosphate pesticides in agricultural lands to control different groups of...
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Development and validation of nomogram for predicting the risk of transferring to the ICU for children with influenza
ObjectiveDevelopment of a nomogram model for predicting the magnitude of risk of transferring hospitalized children with influenza to the ICU.
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Unveiling the overlooked threat: antibiotic resistance in groundwater near an abandoned sulfuric acid plant in **ngyang, China
Groundwater near a sulfuric acid plant in **ngyang, Henan, China was sampled from seven distinct sites to explore the prevalence of antibiotic...
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Bloodstream infections due to multi-drug resistant bacteria in the emergency department: prevalence, risk factors and outcomes—a retrospective observational study
Multidrug-resistant organisms (MDROs) are prevalent in patients admitted to the Emergency Department (ED) and increase the risk of inappropriate...
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Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Background & aimsPatients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed...
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LncRNA PITPNA-AS1 mediates the diagnostic potential of miR-129-5p in prostate cancer
BackgroundLncRNA has an effective value in many diseases, which has long been applied in the diagnosis, treatment and prognosis of prostate cancer....
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Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries
BackgroundThe plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and...
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Machine learning-based prediction of cadmium pollution in topsoil and identification of critical driving factors in a mining area
Mining activities have resulted in a substantial accumulation of cadmium (Cd) in agricultural soils, particularly in southern China. Long-term Cd...
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Phenolic endocrine-disrupting compounds in the **angjiang River: occurrence and risk assessment
The levels of three phenolic endocrine-disrupting compounds (EDCs), NP, BPA and 4-t-OP were determined in water and sediment collected from sites...
