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Association between negative life events and suicidal behavior in adolescents: roles of core self-evaluation, depression and gender
PurposeNegative life events are essential proximal factors that may induce suicidal behavior in adolescents, but the mechanisms connecting this link...
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Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries
BackgroundThe plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and...
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Glial cell transplant for brain diseases: the supportive saviours?
The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still...
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Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine
BackgroundGlaucoma is the leading cause of irreversible blindness worldwide. Normal tension glaucoma (NTG) is a distinct subtype characterized by...
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Explaining Socioeconomic Inequality in Psychological Well-being among Older People: A Comparison between Vietnam and Myanmar
Limited understanding exists regarding the social determinants of psychological well-being inequalities, particularly in develo** countries with...
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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Healthcare costs and medical utilization patterns associated with painful and severe painful diabetic peripheral neuropathy
PurposePainful diabetic peripheral neuropathy (DPN) is a common complication in patients with diabetes. It is associated with a poor quality of life...
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The Role of Prosocial Behaviour in the Deceleration of Conduct Problem Behaviour
While conduct problem behaviour initiated in early childhood often escalates in frequency and seriousness through adolescence, a notable deceleration...
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Consensus paper on the management of acute isolated vertigo in the emergency department
Acute vertigo is defined as the perception of movement of oneself or the surroundings in the absence of actual motion and it is a frequent cause for...
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Assessing large language models’ accuracy in providing patient support for choroidal melanoma
PurposeThis study aimed to evaluate the accuracy of information that patients can obtain from large language models (LLMs) when seeking answers to...
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The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis
BackgroundGastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations such as mutations...
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Brain volume and neurodevelopment at 13 years following sepsis in very preterm infants
BackgroundAssociations of neonatal infection with brain growth and later neurodevelopmental outcomes in very preterm (VP) infants are unclear. This...
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LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
PurposeLong noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with...
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Development and validation of nomogram for predicting the risk of transferring to the ICU for children with influenza
ObjectiveDevelopment of a nomogram model for predicting the magnitude of risk of transferring hospitalized children with influenza to the ICU.
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia
BackgroundExposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure...
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Association of systemic and demographic risk factors with prevalence of retinopathy in US adults with prediabetes
Background/ObjectivesTo investigate the relative contribution of systemic risk factors to retinopathy in prediabetes using a nationally...
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Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
Neuroligin-3 ( Nlgn3 ) is an autism-associated cell-adhesion molecule that interacts with neurexins and is robustly expressed in both neurons and...
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Prevalence of interarm blood pressure difference is notably higher in women; the Viborg population-based screening program (VISP)
BackgroundBilateral blood pressure (BP) measurement is important in cardiovascular prevention for identifying systolic interarm BP difference (IAD)...
