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Heritability of functional gradients in the human subcortico-cortical connectivity
The human subcortex plays a pivotal role in cognition and is widely implicated in the pathophysiology of many psychiatric disorders. However, the...
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Comprehensive analysis of the Xya riparia genome uncovers the dominance of DNA transposons, LTR/Gypsy elements, and their evolutionary dynamics
Transposable elements (TEs) are DNA sequences that can move or replicate within a genome, and their study has become increasingly important in...
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Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA
Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR) with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base...
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Mass spectrometry-based proteomic landscape of rice reveals a post-transcriptional regulatory role of N6-methyladenosine
Rice is one of the most important staple food and model species in plant biology, yet its quantitative proteomes are largely uncharacterized. Here we...
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The neural network RTNet exhibits the signatures of human perceptual decision-making
Convolutional neural networks show promise as models of biological vision. However, their decision behaviour, including the facts that they are...
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Template-independent enzymatic synthesis of RNA oligonucleotides
RNA oligonucleotides have emerged as a powerful therapeutic modality to treat disease, yet current manufacturing methods may not be able to deliver...
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Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in controlled clinical...
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The nature of the last universal common ancestor and its impact on the early Earth system
The nature of the last universal common ancestor (LUCA), its age and its impact on the Earth system have been the subject of vigorous debate across...
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Biotic environment reinforcing the pertinacious clinically relevant COVID-19 associated mucormycosis: First report from Kashmir valley, India
Immuno-compromised COVID-19 patients being treated with glucocorticoids like Dexamethasone for prolonged periods had led to the surge of...
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Species Diversity of Anastrepha Fruit Flies (Diptera: Tephritidae) in Environments with Different Levels of Anthropogenic Changes
Studies on the diversity of Anastrepha species have been conducted mainly in agricultural orchards due to the economic importance of this insect...
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Deep 3D histology powered by tissue clearing, omics and AI
To comprehensively understand tissue and organism physiology and pathophysiology, it is essential to create complete three-dimensional (3D) cellular...
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Vaginal irritation testing—prospects of human organotypic vaginal tissue culture models
Personal lubricants intended for local or systemic delivery via the vaginal route can induce vaginal irritation, damage the vaginal epithelial...
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Biotic regulation of nitrogen gas emissions in temperate agriculture
It is generally assumed that fertilizer addition is the prime driver of nitrogen (N) gas loss from modern crop** systems. This assumption has its...
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Does montane meadow restoration influence the mineral association and stability of soil carbon?
Soil carbon (C) stability is an important consideration for management that aims to increase long-term C storage. The fraction of soil C allocated to...
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Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder
In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that...
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Prevalence of diabetes among Indigenous women in Guatemala: a retrospective chart review
ObjectiveThe objective of this study is to investigate the prevalence of diabetes in a clinical population of primarily Indigenous women in Guatemala.
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