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Systematic review: genetic polymorphisms in the pharmacokinetics of high-dose methotrexate in pediatric acute lymphoblastic leukemia patients
Variations in pharmacokinetic responses to high-dose methotrexate are essential for the prognosis and management of toxicity in the treatment of...
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Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
PurposeAlthough meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only...
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Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different...
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The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and...
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Surgical Perspectives on the Updated ASTRO Guideline on Partial Breast Irradiation for Breast Cancer
This is an executive summary of the most recent American Society for Radiation Oncology (ASTRO) guidelines on use of partial breast irradiation in...
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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
BackgroundAcetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116)...
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Fine map** of interspecific secondary CSSL populations revealed key regulators for grain weight at qTGW3.1 locus from Oryza nivara
Grain weight (GW) is the most important stable trait that directly contributes to crop yield in case of cereals. A total of 105 backcross...
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Susceptibility gene mutations in germline and tumors of patients with HER2-negative advanced breast cancer
Germline mutations in BRCA1 and BRCA2 (g BRCA1/2 ) are required for a PARP inhibitor therapy in patients with HER2-negative (HER2−) advanced breast...
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Extreme Oncoplasty: Oncologically Safe When Compared with Mastectomy
BackgroundExtreme oncoplasty is a breast-conserving operation using oncoplastic techniques in a patient who does not meet the traditional criteria...
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Genetic Clustering of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Patients of Colorectal Origin: KRAS and Not TP53 Cluster Alterations are Associated with Poor Outcomes
BackgroundThe prognostic impact of genetic mutations for patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal...
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Preoperative Prediction of Muscle Invasiveness in Bladder Cancer: The Role of 3D Volumetric Radiomics Using Diffusion-Weighted MRI, the VI-RADS Score, or a Combination of Both
BackgroundBladder cancer treatment decisions hinge on detecting muscle invasion. The 2018 “Vesical Imaging Reporting and Data System” (VI-RADS)...
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The Effect of Oxidative Stress and Antioxidants Treatment on Gestational Diabetes Mellitus Outcome: A Sco** Review
Diagnosing a pregnant woman’s glucose intolerance is referred to as gestational diabetes mellitus (GDM). Diabetes has been linked to enhanced...
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Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study
BackgroundWe previously demonstrated the applicability of the concept of “platinum sensitivity” in recurrent endometrial cancer. Although immune...
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Avian Diversity: A Comprehensive Bird Checklist of Graphic Era (Deemed to be University), Dehradun (Western Himalaya), India
AbstractThe present study aims to provide a comprehensive bird checklist of Graphic Era (Deemed to be University), Dehradun, India. The study was...
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Effects of Bacillus thuringiensis var. israelensis Strains and Toxins on the Pine Processionary Moth Thaumetopoea wilkinsoni (Lepidoptera: Notodontidae)
AbstractThe pine processionary moth Thaumetopoea wilkinsoni (Tams, 1926) (Lepidoptera: Notodontidae) is one of the most harmful species that causes...
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Reference Gene Selection for Expression Analysis of Hepatic Genes Responding to Fasting via Transcriptomic Analysis
AbstractThe liver of mammals is a critical organ that houses numerous physiological processes, including macronutrient metabolism. Regarding nutrient...
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Simultaneous Application of Ascorbic Acid and Proline as a Smart Approach to Mitigate the Adverse Effects of Salt Stress in Wheat (Triticum aestivum)
AbstractThe effects of exogenously applied ascorbic acid (AsA, 1 mM) and proline (Pro, 1 mM), were evaluated on the growth, nutritional behavior,...
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The Status and Distributions of the Wild Olive (Olea europaea subsp. europaea var. sylvestris) in Muğla Province and Its Islands under Global Climate Change
AbstractThe olive is an economically important and indispensable species of the Mediterranean basin with remarkable historic and cultural...
