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Advances in injectable hydrogels with biological and physicochemical functions for cell delivery
Injectable hydrogels that can be administered via syringes have enormous potential as cell delivery carriers for cell transplantation therapy. Owing...
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Targeting ROS in cancer: rationale and strategies
Reactive oxygen species (ROS) in biological systems are transient but essential molecules that are generated and eliminated by a complex set of...
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Effect of acetylation on wood-water interactions studied by sorption calorimetry
Sorption of water has a profound effect on the material properties of wood. The uptake of water vapour in wood and other materials releases more heat...
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Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene
HSPB8 is a heat shock protein belonging to a family of ATP-independent stress proteins called HSPB which are present far and wide in the cells of...
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Facile and cost-effective optical sensing of abamectin and ivermectin using gold nanoparticles conjugated with organosilicon compound and on cellulose filter paper
This study presents a novel, facile, and low-cost method for the separation and sensing of two closely related antiparasitic drugs, abamectin (ABM)...
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Simultaneous multi-site editing of individual genomes using retron arrays
During recent years, the use of libraries-scale genomic manipulations scaffolded on CRISPR guide RNAs have been transformative. However, these...
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Conjugation with the Carrier Helped to Reveal acidification-Induced Structural Shift in the Peptide from Phospholipase Domain of Parvovirus B19
Spectroscopic studies on domains and peptides of large proteins are complicated because of the tendency of short peptides to form oligomers in...
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Controlled synthesis of cylindrical micelles via crystallization-driven self-assembly (CDSA) and applications
Recently, crystallization-driven living self-assembly (CDSA) has attracted much attention for its ability to generate 1D cylindrical micelles and...
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Pharmacological Doses of Thiamine Benefit Patients with the Charcot–Marie–Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes
AbstractCharcot–Marie–Tooth (CMT) neuropathy is a polygenic disorder of peripheral nerves with no effective cure. Thiamine (vitamin B1) is a...
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Computational and Experimental Approaches Towards Understanding the Role of ATG8 in Autophagy: A Therapeutic Paradigm in Leishmaniasis
In the realm of parasitology, autophagy has emerged as a critical focal point, particularly in combating Leishmaniasis. Central to this endeavour is...
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Multiple Protein Profiler 1.0 (MPP): A Webserver for Predicting and Visualizing Physiochemical Properties of Proteins at the Proteome Level
Determining the physicochemical properties of a protein can reveal important insights in their structure, biological functions, stability, and...
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Engineering miniature IscB nickase for robust base editing with broad targeting range
IscB has a similar domain organization to Cas9, but the small size of IscB is better suited for delivery by adeno-associated virus. To improve the...
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Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system
Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems are prokaryotic adaptive immune systems against invading phages and...
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Investigating the effect of cerium oxide nanoparticle on beta-amyloid-induced memory loss
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the loss of nerve cells in the hippocampus region of the brain, leading to...
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Synthesis and anti-leishmanial activities of uniflorol analogues
Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and synthetic derivatives....
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Distinct phases of cellular signaling revealed by time-resolved protein synthesis
The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this...
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Assessing and engineering the IscB–ωRNA system for programmed genome editing
OMEGA RNA (ωRNA)-guided endonuclease IscB, the evolutionary ancestor of Cas9, is an attractive system for in vivo genome editing because of its...
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Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan carboxamide and Schiff base derivatives were evaluated for their hypolipidemic activity. Fourteen derivatives were synthesised:...
