Search
Search Results
-
Three-dimensional saturated C(sp3)-rich bioisosteres for benzene
Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are frequently associated with poor ‘drug-like’ properties,...
-
LAFeBS, alive, kicking, and growing: the story continues…
This Commentary describes a call for contributions to an upcoming Special Issue (SI) of Biophysical Reviews on the Latin American Federation of...
-
Intratumoral Delivery of Genetically Engineered Anti-IL-6 Trans-signaling Therapeutics
Interleukin-6 (IL-6) is a highly pro-inflammatory cytokine involved in the etiopathology of several inflammatory diseases and cancer. As so, the...
-
Association between OX40L polymorphism and type 2 diabetes mellitus in Iranians
IntroductionDiabetes mellitus (DM) is one of the leading causes of morbidity and mortality worldwide. It is a multifactorial disease that genetic and...
-
An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer
Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a...
-
Population dynamics and genetic isolation in the Central Himalayan region: insights from Sikkim population, India
India’s rich diversity encompasses individuals from varied geographical, cultural, and ethnic backgrounds. In the field of population genetics,...
-
Metabolomic and lipidomic profiling of the spinal cord in type 2 diabetes mellitus rats with painful neuropathy
In this paper we investigated lipid and metabolite changes in diabetic neuropathy, using untargeted lipidomics and metabolomics analyses of the...
-
Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Exhaled breath volatilomics is a powerful non-invasive tool for biomarker discovery in medical applications, but compound annotation is essential for...
-
Genetic factors of oocyte maturation arrest: an important cause for recurrent IVF/ICSI failures
Oocyte maturation arrest (OMA) is a common phenotype observed in IVF/ICSI cycles, characterized by the production of immature oocytes which lead to...
-
-
Androgen transition and management of hereditary angioedema long-term prophylaxis in real life: a single-center case series
BackgroundHereditary angioedema (HAE) is a rare and potentially life-threatening disease that manifests clinically as recurrent episodes of swelling...
-
Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation
Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and...
-
Identifying key genes and functionally enriched pathways in acute myeloid leukemia by weighted gene co-expression network analysis
Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of myeloid leukemia cells in the bone marrow and other hematopoietic...
-
The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individuals. The pathogenesis of Toxoplasma...
-
Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma
Renal cell carcinoma (RCC) is a malignant tumor originating from the epithelial cells of the renal tubules. The clear cell RCC subtype is closely...
-
Simultaneous multi-site editing of individual genomes using retron arrays
During recent years, the use of libraries-scale genomic manipulations scaffolded on CRISPR guide RNAs have been transformative. However, these...
-
Chronoamperometric response of electrochemical reaction diffusion system: a new theoretical and numerical investigation for EC2 scheme
This paper introduces a novel mathematical model for chronoamperometric analysis of electrochemical reactions in the EC2 scheme. Utilizing the...
