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Pipette-tip solid-phase extraction coupled with matrix-assisted laser desorption/ionization mass spectrometry enables rapid and high-throughput analysis of antidepressants in rat serum
Therapeutic drug monitoring is essential for ensuring the efficacy and safety of medications. This study introduces a streamlined approach that...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission
Dietary salt is increasingly recognized as an independent risk factor for cognitive impairment. However, the exact mechanisms are not yet fully...
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Production of a bacterial secretome highly efficient for the deconstruction of xylans
Bacteria within the Paenibacillus genus are known to secrete a diverse array of enzymes capable of breaking down plant cell wall polysaccharides. We...
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Design of Experiments-Driven Optimization of Spray Drying for Amorphous Clotrimazole Nanosuspension
This study employed a Quality by Design (QbD) approach to spray dry amorphousclotrimazole nanosuspension (CLT-NS) consisting of Soluplus ® and...
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Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC
Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular disorders, such as coronary heart disorder, hypertension,...
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Fluorescence Recognition of Hydrazine Driven by Neighboring Group Participation
Hydrazine (N 2 H 4 ) has toxic effects on the environment. Although a variety of reactive probes have been used to identify hydrazine, practical...
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Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain
BackgroundFrontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant...
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Antibody MYH9 and Antibiotic Lidamycin Inhibit the Growth and Proliferation of Lung Cancer Cells and Induce Their Apoptosis
The aim of this study was to investigate the impact of the antibiotic lidamycin (LDM) and the targeted therapy with the antibody Myosin heavy chain 9...
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MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting...
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Multiple comparisons of acetylene black–based rigid composite electrodes: comprehensive evaluation of chemical properties and electrochemical sensing potentialities
We report the comparison of multiple acetylene black (AB) rigid carbon composites for electrochemical purposes exploring several binders, including...
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Exergy analysis of direct method for conversion of natural gas to methanol
The exergy analysis of a direct method for the conversion of natural gas to methanol is reported in this work. The study is part of a process...
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IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these...
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Progress and perspectives of metabolic biomarkers in human aortic dissection
BackgroundAortic dissection (AD) significantly threated human cardiovascular health, extensive clinical-scientific research programs have been...
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Duo photoprotective effect via silica-coated zinc oxide nanoparticles and Vitamin C nanovesicles composites
ObjectiveZinc Oxide nanoparticles (ZnO NPs) are used widely in nowadays personal care products, especially sunscreens, as a protector against UV...
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Underlying Mechanism of Fluoride Inhibits Colonic Gland Cells Proliferation by Inducing an Inflammation Response
The integrity of colonic gland cells is a prerequisite for normal colonic function and maintenance. To evaluate the underlying injury mechanisms in...
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Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae
Plants display tremendous chemical diversity. Like all organisms, they possess a core set of metabolites for growth and development. However, plants...
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KKL-35 inhibits growth of Staphylococcus aureus by systematically changing bacterial phenotypes
KKL-35 is a new oxadiazole compound with potent broad-spectrum antibacterial activity against a number of gram-positive and gram-negative bacteria....
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Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
