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New Frontiers on Intracellular cGAS Activation: Molecular Mechanisms, Cellular Signaling, and Therapeutic Strategies
Cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a pivotal role in the innate immune system. As the primary DNA sensor in cells, cGAS binds to dsDNA in...
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Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae
Plants display tremendous chemical diversity. Like all organisms, they possess a core set of metabolites for growth and development. However, plants...
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Duo photoprotective effect via silica-coated zinc oxide nanoparticles and Vitamin C nanovesicles composites
ObjectiveZinc Oxide nanoparticles (ZnO NPs) are used widely in nowadays personal care products, especially sunscreens, as a protector against UV...
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KKL-35 inhibits growth of Staphylococcus aureus by systematically changing bacterial phenotypes
KKL-35 is a new oxadiazole compound with potent broad-spectrum antibacterial activity against a number of gram-positive and gram-negative bacteria....
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Research Progress on Bio-inspired Flap**-Wing Rotor Micro Aerial Vehicle Development
Flap**-wing rotor (FWR) is an innovative bio-inspired micro aerial vehicle capable of vertical take-off and landing. This unique design combines...
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AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans
Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme...
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Underlying Mechanism of Fluoride Inhibits Colonic Gland Cells Proliferation by Inducing an Inflammation Response
The integrity of colonic gland cells is a prerequisite for normal colonic function and maintenance. To evaluate the underlying injury mechanisms in...
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Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline
BackgroundThe cerebrospinal fluid (CSF), primarily generated by the choroid plexus (ChP), is the major carrier of the glymphatic system. The...
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Exosome theranostics: Comparative analysis of P body and exosome proteins and their mutations for clinical applications
Exosomes are lipid-bilayered vesicles, originating from early endosomes that capture cellular proteins and genetic materials to form multi-vesicular...
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Unleashing the Neurotherapeutic Potential: The Crucial Role of miR-206-3p in Facilitating Hsp90aa1-Mediated Central Nervous System Injuries During Heat Stroke
This study aims to explore the molecular mechanisms of miR-206-3p in regulating Hsp90aa1 and its involvement in the central nervous system (CNS)...
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[H2dab][GaB5O10]: an Acentric Galloborate with a 4-Connected Uninodal Framework
A new acentric galloborate (GBO) [H 2 dab][GaB 5 O 10 ] ( 1 , 1,4-dab: 1,4-diaminobutane) has been synthesized under solvothermal conditions. The alternation...
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HSPiP, Computational, and Thermodynamic Model–Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus‑Based In Vivo Prediction in Humans: Part II
In part I, we reported Hansen solubility parameters (HSP, HSPiP program), experimental solubility at varied temperatures for TOTA delivery. Here, we...
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Kinetic Modeling for BT200 to Predict the Level of Plasma-Derived Coagulation Factor VIII in Humans
Lack of Factor VIII (FVIII) concentrates is one of limiting factors for Hemophilia A prophylaxis in resource-limited countries. Rondaptivon pegol...
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Neutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic....
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Nanosuspension-Based Repaglinide Fast-Dissolving Buccal Film for Dissolution Enhancement
Drug solubility and dissolution remain a significant challenge in pharmaceutical formulations. This study aimed to formulate and evaluate...
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Optimization of Total DNA Extraction from Dried Blood Samples
While dried blood spots are a convenient source of genetic material, they are usually associated with a lower DNA yield than from a native sample....
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Exploring the Predominant Factors Influencing the Oxygen Reduction Performance of PtCo/C Catalysts
PtCo nanoalloys (NAs) deposited on carbon black are emerging as robust electrocatalysts for addressing the sluggish kinetic issue of oxygen reduction...
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A Scalable Pillar Layered Metal-Organic Framework for Natural Gas Purification
One-step harvest of high-purity methane (CH 4 ) from ternary propane/ethane/methane (C 3 H 8 /C 2 H 6 /CH 4 ) mixtures remains a desirable yet challenging goal...
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TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway
BackgroundThe neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF...
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Alpha-expansins: more than three decades of wall creep and loosening in fruits
Expansins are proteins without catalytic activity, but able to break hydrogen bonds between cell wall polysaccharides hemicellulose and cellulose....