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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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Extreme Oncoplasty: Oncologically Safe When Compared with Mastectomy
BackgroundExtreme oncoplasty is a breast-conserving operation using oncoplastic techniques in a patient who does not meet the traditional criteria...
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Genetic Clustering of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Patients of Colorectal Origin: KRAS and Not TP53 Cluster Alterations are Associated with Poor Outcomes
BackgroundThe prognostic impact of genetic mutations for patients who undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal...
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Preoperative Prediction of Muscle Invasiveness in Bladder Cancer: The Role of 3D Volumetric Radiomics Using Diffusion-Weighted MRI, the VI-RADS Score, or a Combination of Both
BackgroundBladder cancer treatment decisions hinge on detecting muscle invasion. The 2018 “Vesical Imaging Reporting and Data System” (VI-RADS)...
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Optimising a digitally delivered behavioural weight loss programme: study protocol for a factorial cluster randomised controlled trial
BackgroundDigitally delivered weight loss programmes can provide a convenient, potentially cheaper, and scalable treatment option for people who may...
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Comparison of outcomes after unplanned conversion for patients undergoing robotic when compared with laparoscopic colectomy
The robotic approach improves the feasibility of minimally invasive colectomy even where there may be an anatomic challenge with laparoscopy. Whether...
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Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis
Common psychiatric disorders constitute one of the most substantial healthcare burdens worldwide. However, drug development in psychiatry remains...
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High-risk pathogenic germline variants in blood relatives of BRCA1/2 negative probands
BackgroundTailored, preventive cancer care requires the identification of pathogenic germline variants (PGVs) among potentially at-risk blood...
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Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries
BackgroundThe plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and...
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Domain adaptation using AdaBN and AdaIN for high-resolution IVD mesh reconstruction from clinical MRI
PurposeDeep learning has firmly established its dominance in medical imaging applications. However, careful consideration must be exercised when...
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Glial cell transplant for brain diseases: the supportive saviours?
The incidence of brain diseases in humans is increasing as we experience a worldwide ageing of the population. Treatment for such diseases is still...
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The current landscape of global international surgical rotations for general surgery residents in the United States: a survey by the Association for Program Directors in Surgery’s (APDS) global surgery taskforce
As interest in global surgery increases among surgical trainees, more programs are incorporating global surgery rotations into residency training....
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Impact of hepatocyte growth factor on the colonic morphology and gut microbiome in short bowel syndrome rat model
PurposeThis study aimed to investigate the impact of hepatocyte growth factor (HGF) on colonic morphology and gut microbiota in a rat model of short...
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Platelet-Rich Plasma for Knee and Hip Osteoarthritis Pain: A Sco** Review
Purpose of ReviewPlatelet-rich plasma (PRP) is an emerging biological intervention for osteoarthritis (OA), yet the outcomes remain uncertain. The...
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Assessing large language models’ accuracy in providing patient support for choroidal melanoma
PurposeThis study aimed to evaluate the accuracy of information that patients can obtain from large language models (LLMs) when seeking answers to...
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Brain volume and neurodevelopment at 13 years following sepsis in very preterm infants
BackgroundAssociations of neonatal infection with brain growth and later neurodevelopmental outcomes in very preterm (VP) infants are unclear. This...
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The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia
BackgroundExposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure...
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Association of systemic and demographic risk factors with prevalence of retinopathy in US adults with prediabetes
Background/ObjectivesTo investigate the relative contribution of systemic risk factors to retinopathy in prediabetes using a nationally...
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ASO Visual Abstract: Open Versus Minimally Invasive Nephroureterectomy: Contemporary Analysis from a Wide National Population-Based Database
Contemporary trend analysis of a large national data set confirms the occurrence of a significant shift toward minimally invasive nephroureterectomy...