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Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
BackgroundHyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The...
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Development and preliminary evaluation of a suicidal risk assessment protocol in a randomised controlled trial using the Patient Health Questionnaire (PHQ-9)
BackgroundParticipants in research trials often disclose severe depression symptoms, including thoughts of self-harm and suicidal ideation, in...
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Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health...
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Exploring paramedics’ lived experiences in confrontation with patients’ death during missions: a phenomenological study
BackgroundEmergency personnel are the first line of emergency response systems to respond to emergencies; in essence, they are usually exposed to a...
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Improving the introduction of telemedicine in pre-hospital emergency medicine: understanding users and how acceptability, usability and effectiveness influence this process
IntroductionIncreasing numbers of ambulance calls, vacant positions and growing workloads in Emergency Medicine (EM) are increasing the pressure to...
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Mucinous tubular and spindle renal cell carcinoma revealed by a trauma of the kidney: a case report
BackgroundMucinous tubular and spindle cell carcinoma is a rare renal tumor. It has been recognized as a distinct entity in the 2004 World Health...
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Healthcare delivery to patients from culturally and linguistically diverse backgrounds in emergency care: a sco** review protocol
BackgroundWorldwide, the culturally and linguistically diverse (CALD) population is increasing, and is predicted to reach 405 million by 2050. The...
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Nourishing Physical Productivity and Performance On a Warming Planet - Challenges and Nutritional Strategies to Mitigate Exertional Heat Stress
Purpose of ReviewClimate change is predicted to increase the frequency and severity of exposure to hot environments. This can impair health, physical...
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Effectiveness of smoking cessation interventions among adults: an overview of systematic reviews
BackgroundThis overview of reviews aims to identify evidence on the benefits (i.e. tobacco use abstinence and reduction in smoking frequency) and...
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Wearable cuffless blood pressure tracking: when will they be good enough?
Wearable health monitoring is a multibillion-dollar industry. But the holy grail is probably getting it right for blood pressure monitoring without a...
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Spectrum of Oral Lesions Histopathologically Diagnosed at the Faculty of Dentistry, Universidad de Costa Rica
The oral mucosa presents different lesions and conditions, which must be identified through a systematic and detailed examination of the oral cavity...
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A randomized controlled trial to assess if changing sleep timing can improve glucose metabolism in people with prediabetes and type 2 diabetes
BackgroundSocial jetlag is a chronic disruption of sleep timing that is characterized by different sleep timing during workdays and free days. Social...
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Woven coronary artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography
Woven coronary artery (WCA) is a rare anomaly and its etiology remains speculative. Both congenital and acquired factors are considered to be...
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Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)
BackgroundBilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic...
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A cognitive-behavioral treatment for suicide prevention among adults with schizophrenia spectrum disorders in community mental health: Study protocol for a pilot feasibility and acceptability randomized clinical trial
BackgroundSuicide is among the leading causes of death for adults with schizophrenia spectrum disorders (SSDs), and there is a paucity of...
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An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
BackgroundTo explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
MethodsBased on TCGA and GTEx databases, we used TIMER2.0...
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Comparative analysis of reduced toxicity conditioning regimens between fludarabine plus melphalan and fludarabine plus busulfex in adult patients with acute lymphoblastic leukemia
Reduced-toxicity conditioning (RTC) regimens aim to mitigate regimen-related toxicity while maintaining anti-leukemic efficacy in allogeneic...