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Rapid evolution of promoters from germline-specifically expressed genes including transposon silencing factors
BackgroundThe piRNA pathway in animal gonads functions as an ‘RNA-based immune system’, serving to silence transposable elements and prevent...
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Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
The use of modified nucleotides to suppress the interferon response and maintain translation of self-amplifying RNA (saRNA), which has been achieved...
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Map** the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq
Currently, the dynamic accessible elements that determine regulatory programs responsible for the unique identity and function of each cell type...
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Evaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi ( R. equi ) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and...
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YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6
ObjectiveRetinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs...
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Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF
BackgroundThe precise mechanisms leading to the development of heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. In...
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The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis
Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by...
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Genome sequencing of SARS-Co-V-2 reveals mutations including F559I and V781D in S protein and LI123-124L in the nsp6 in 21K and 21L clades
Contagious and virulent virus variants like B.1.1.529 have complicated the 2019 global COVID-19 pandemic from Wuhan, China. Omicron, with extensive...
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Thermal divergence in a color polymorphic lizard inhabiting contrasting environments in central Mexico
The niche partitioning hypothesis predicts differential use of resources among morphs depending on resource dynamics and morph frequencies....
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Enhanced recombination empowers the detection and map** of Quantitative Trait Loci
Modern plant breeding, such as genomic selection and gene editing, is based on the knowledge of the genetic architecture of desired traits....
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A global evaluation of mitochondrial DNA diversity and distribution of dromedary, Camelus dromedarius from north-central Saudi Arabia
Knowledge of genetic variability within and among types and breeds of dromedary ( Camelus dromedarius L.) can be a valuable asset in selective...
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Computational gastronomy: capturing culinary creativity by making food computable
Cooking, a quintessential creative pursuit, holds profound significance for individuals, communities, and civilizations. Food and cooking transcend...
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Description of a new vagrant Aceria species (Acari: Eriophyidae) on Artemisia scoparia Waldst. & Kit. (Asteraceae) in northwest Iran and a key to the world species associated with Artemisia spp.
To fill the gap of eriophyoid mites in Iran, a field survey was carried out in northwest Iran (Aras dam lake, West Azerbaijan Province), in summer...
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Thirteen new species of Urucumania (Phasmatodea: Pseudophasmatidae) stick insects from Brazil and Bolivia
Stick insects (Phasmatodea) in general are remarkable for presenting striking camouflage-related adaptations. Even so, a considerable number of...
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Dietary restriction promote sperm remodeling in aged roosters based on transcriptome analysis
BackgroundThe breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30...
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VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains
Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells. Despite their abundance, our understanding of branched Ub...
