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Nanoarchitectonics for synergistic activity of multimetallic nanohybrids as a possible approach for antimicrobial resistance (AMR)
The global threat posed by antimicrobial resistance (AMR) to public health is an immensurable problem. The effectiveness of treating infections would...
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Oxidative stress across multiple tissues in house sparrows (Passer domesticus) acclimated to warm, stable cold, and unpredictable cold thermal treatments
With climate change increasing not just mean temperatures but the frequency of cold snaps and heat waves, animals occupying thermally variable areas...
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Giant milkweed: a comprehensive review of chemical constituents and their insecticidal properties
Calotropis gigantea (L.) W.T. Aiton, a common barren land weed, referred to as Giant Milkweed, has attracted considerable attention due to its rich...
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A novel homozygous missense TTC12 variant identified in an infertile Pakistani man with severe oligoasthenoteratozoospermia and primary ciliary dyskinesia
TTC12 is a cytoplasmic and centromere-localized protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both...
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Airways Relaxant and Antiasthmatic Activity of Aconitum heterophyllum Wall ex Royle. Roots: A Mechanistic Insight
Aconitum heterophyllum Wall ex Royle. (Ranunculaceae) is a traditional medicinal herb that has shown extensive pharmacological potential to treat...
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Polyphenols and terpenoids derived from Ocimum species as prospective hepatoprotective drug leads: a comprehensive mechanistic review
The hepatic regulatory role in metabolism involves exposure to a diverse array of xenobiotic compounds leading to the potential accumulation of...
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Identification of tomato F-box proteins functioning in phenylpropanoid metabolism
Phenylpropanoids, a class of specialized metabolites, play crucial roles in plant growth and stress adaptation and include diverse phenolic compounds...
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Vaginal irritation testing—prospects of human organotypic vaginal tissue culture models
Personal lubricants intended for local or systemic delivery via the vaginal route can induce vaginal irritation, damage the vaginal epithelial...
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Dramatic loss of microbial viability in bentonite exposed to heat and gamma radiation: implications for deep geological repository
Bentonite is an integral part of the engineered barrier system (EBS) in deep geological repositories (DGR) for nuclear waste, but its indigenous...
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The Goldilocks Dilemma: the optimal management strategy for invasive trees in the Atlantic Forest
This study addresses the broader issue of invasive species management, particularly within the context of highly biodiverse yet threatened ecosystems...
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Navigating the complexity of p53-DNA binding: implications for cancer therapy
AbstractThe tumor suppressor protein p53, a transcription factor playing a key role in cancer prevention, interacts with DNA as its primary means of...
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Biodegradation of the cyanobacterial toxin anatoxin-a by a Bacillus subtilis strain isolated from a eutrophic lake in Saudi Arabia
Anatoxin-a (ATX-a) is a neurotoxin produced by some species of cyanobacteria. Due to its water solubility and stability in natural water, it could...
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Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications
The present study deals with the bio-fabrication of AgA-AgNPs utilizing edible mushroom Agaricus arvensis as a reductant for improved stability and...
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Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development remains elusive. Previous...
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“Effect of Sunset Yellow on Testis: Molecular Evaluation, and Protective Role of Coenzyme Q10 in Male Sprague-Dawley Rats”
In recent years, Sunset Yellow (SY) has been widely used as a food additive, sparking debates about its potential toxicity. This research aims to...
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YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes
Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have...
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Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers
Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to...
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Fractal morphology of mechanosensory lateral-line canals in Stichaeidae
The marine teleost family Stichaeidae shows considerable variation in the morphology of mechanosensory lateral-line canals across its six...
