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Elucidating of Fluconazole Cocrystallization With a Cutting-Edge Nutraceutical Coformer for Enhanced Formulation Strategies
IntroductionThis current research reports the synthesis and characterization of a cocrystal of Fluconazole (FLU), a widely used antifungal drug, with...
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Hesperidin/Salinomycin Combination; a Natural Product for Deactivation of the PI3K/Akt Signaling Pathway and Anti-Apoptotic Factors in KG1a Cells
AML is a highly aggressive malignant clonal disease of hematopoietic origin. Hesperidin as a polyphenol glycoside, Activates the apoptotic pathway...
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Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals....
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Unveiling the Detrimental Effect of Glipizide on Structure and Function of Catalase: Spectroscopic, Thermodynamics and Simulation Studies
Free radicals, products of oxidative processes, induce cellular damage linked to diseases like Parkinson's and diabetes due to increased reactive...
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Synthesis, Invitro Cytotoxic Activity and Optical Analysis of Substituted Schiff Base Derivatives
Fluorescent cytotoxic compounds with readout delivery are crucial in chemotherapy. The growing demands of these treatment strategies require the...
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A Ratiometric Fluorescence Probe Based on Silver Nanoclusters and CdSe/ZnS Quantum dots for the Detection of Hydrogen Peroxide by Aggregation and Etching
In this study, a ratiometric fluorescence nanoprobe is developed for the analysis of hydrogen peroxide (H 2 O 2 ). Silver nanoclusters (AgNCs) were...
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Optimizing Nimesulide Loaded Cubosomal Gel for Enhanced Efficacy: A Systematic Engineering Approach with Factorial Design for Topical Applications
PurposeThe primary aim of this study is to develop a cubosome nanoformulation for the optimized delivery of nimesulide, with a focus on improving its...
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Iron Oxide-Doped Carbon Nanoparticles Stabilised with Functionally Modified Hyperbranched Polyglycerol for Cd2+ Sensing and Photodynamic Antibacterial Therapeutic Applications
Nanoscale materials are being developed from individual particles to multi-component assemblies, with carbon nanomaterials being particularly useful...
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Preparation and Judd-Ofelt Analysis of Warm Red Luminescent Eu3+ Complexes for Semiconductor Lasing Devices
Six novel red photoluminescent Eu 3+ complexes with 3-formyl chromone as the primary sensitizer (L) were synthesized using the solution precipitation...
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Laser-mediated Solutions: Breaking Barriers in Transdermal Drug Delivery
Skin diseases pose challenges in treatment due to the skin’s complex structure and protective functions. Topical drug delivery has emerged as a...
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Defining the Range of Calibration Burden: From Full Calibration to Calibration-Free
The expansion of spectroscopic process analytical technology (PAT) within the pharmaceutical industry requires chemometric models to enable spectral...
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Active Hydrogen Free, Z-Isomer Selective Isatin Derived “Turn on” Fluorescent Dual Anions Sensor
An efficient and anions fluorescence “on–off” sensor of 1-(prop-2-yn-1-yl)-3-(quinolin-3-ylimino)indolin-2-one (PQI) has been developed for the...
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Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells
Chemotherapeutic agents often lack specificity, intratumoral accumulation, and face drug resistance. Targeted drug delivery systems based on...
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Development and Evaluation of Stable Long Circulating Decitabine-loaded Copolymeric Nanoparticles: Harnessing QbD Approach and Lyophilization Technique
PurposeDecitabine is an inhibitor of DNA methyltransferase used to treat various types of leukemias. However, it is highly unstable in nature thereby...
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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis
Biologics have become increasingly prominent as therapeutics in recent years due to their innate immune-privileged nature, biocompatibility, and high...
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Chitosan-Derived Nanocarrier Polymers for Drug Delivery and pH-Controlled Release in Type 2 Diabetes Treatment
Diabetes, particularly Type 2 Diabetes Mellitus (T 2 DM), is a chronic metabolic disorder with high and increasing global prevalence, characterized by...
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Low-temperature Co-precipitation Synthesis of ZnAl2O4 Nanophosphors Probing its Luminescent, Antibacterial and Anticancer Potentials
Metal nanoparticles and their binary oxides are well-known for their interactions with biomolecules and their applications in the biomedical field....
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Potential of Powder Rheology for Detecting Unforeseen Cross-Contamination of Foreign Active Pharmaceutical Ingredients
Unexpected cross-contamination by foreign components during the manufacturing and quality control of pharmaceutical products poses a serious threat...
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Stealth Nanocarriers in Cancer Therapy: a Comprehensive Review of Design, Functionality, and Clinical Applications
Nanotechnology has significantly transformed cancer treatment by introducing innovative methods for delivering drugs effectively. This literature...
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Exploiting and Enhancing the Heat Transport Rate of MoS2-Ag/EO Hybrid Nanofluid Flow via a Stretching Cylinder using Extended Yamada–Ota and Xue Models
The current model offers valuable insights for materials science, heat exchangers, renewable energy production, nanotechnology, manufacturing,...
