270 Result(s)

Article

LncRNA IRAR regulates chemokines production in tubular epithelial cells thus promoting kidney ischemia-reperfusion injury

Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play an important role in several pathogenic processes of the kidney. However, functions of lncRNAs in ischemic acute kidney injury (AKI) rem...

** Jia, Sujuan Xu, Ting Ren, Tianyi Pan, … in Cell Death & Disease (2022)

Article

SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma

SGLT2 (sodium-glucose cotransporter 2) is an important mediator of epithelial glucose transport and has been reported that SGLT2, robustly and diffusely expressed in malignant cancer cells, was overexpressed i...

Wei Wu, Zhenhao Zhang, Doudou **g, **n Huang, Dianyun Ren… in Cell Death & Disease (2022)

Article

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function. While the ER participates in a number of biologica...

Yiran E. Li, James R. Sowers, Claudio Hetz, Jun Ren in Cell Death & Disease (2022)

Article

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming

The antioxidant transcription factor NFE2L1 (also called Nrf1) acts as a core regulator of redox signaling and metabolism homeostasis, and thus, its dysfunction results in multiple systemic metabolic diseases....

Lu Qiu, Qiufang Yang, Wenshan Zhao, Yadi **ng, Peng Li… in Cell Death & Disease (2022)

Article

Antibiotic pretreatment attenuates liver ischemia–reperfusion injury by Farnesoid X receptor activation

Prophylactic antibiotics (Abx) are used before liver surgery, and the influence of antibiotic pretreatment on hepatic ischemia–reperfusion injury (IRI) remains unclear. Hence, we explored the impact of Abx pre...

Hanyi Liu, **glin Wang, Yitao Ding, **aolei Shi, Haozhen Ren in Cell Death & Disease (2022)

Article

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, with high incidence and mortality rates and low survival rates. However, the detailed molecular mechanism of ESCC progress...

Yingtong Feng, Zhiqiang Ma, Minghong Pan, Liqun Xu, Junjun Feng… in Cell Death & Disease (2022)

Article

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of th...

Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram… in Cell Death & Disease (2022)

Article

FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development

SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, migration and promoting apoptosis. However, the post-translational regulatio...

**g Ji, **g Shen, Yuxin Xu, Mengru **e, Qilan Qian, Teng Qiu… in Cell Death & Disease (2022)

Article

CD4⁺ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer

As a widely studied adoptive treatment method, CIK (cytokine-induced killer cells) treatment has shown clinical benefits in many clinical trials on non-small cell lung cancer. As a heterogeneous cell populatio...

Shaochuan Liu, Yuan Meng, Liang Liu, Yingge Lv, Wenwen Yu, Ting Liu… in Cell Death & Disease (2022)

Article

Correction: Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy

Danyang Shi, **hua Ding, Shouqiang **e, Lei Huang, Hongmin Zhang… in Cell Death & Disease (2022)

Article

Global characterization of extrachromosomal circular DNAs in advanced high grade serous ovarian cancer

High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer and HGSOC patients often appear with metastasis, leading to the poor prognosis. Up to date, the extrachromosomal circul...

Yixuan Cen, Yifeng Fang, Yan Ren, Shiyuan Hong, Weiguo Lu… in Cell Death & Disease (2022)

Article

Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis

Sepsis is a systemic inflammatory state in response to infection, and concomitant acute kidney injury (AKI) significantly increases morbidity and mortality. Growing evidence suggests that fatty acid-binding pr...

Bo Wang, Jun Xu, Qian Ren, Lu Cheng, Fan Guo, Yan Liang… in Cell Death & Disease (2022)

Article

PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells

A high plasma level of the choline-derived metabolite trimethylamine N-oxide (TMAO) is closely related to the development of cardiovascular disease. However, the underlying mechanism remains unclear. In the pr...

He Liu, Kunpeng Jia, Zhengnan Ren, Jia Sun, Li-Long Pan in Cell Death & Disease (2022)

Article

ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway

The present study was performed to explore whether and how impaired autophagy could modulate calcium/calmodulin-dependent protein kinase II (CAMKII)-regulated necrosis in the pathogenesis of acute pancreatitis...

Liang Ji, Zhi-hong Wang, Yu-hua Zhang, Yi Zhou, De-sheng Tang… in Cell Death & Disease (2022)

Article

Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway

BRCA1 deficient breast cancers are aggressive and chemoresistant due, in part, to their enrichment of cancer stem cells that can be generated from carcinoma cells by an epithelial-mesenchymal transition (EMT)....

Feng Bai, Chuying Wang, **ong Liu, Daniel Hollern, Shiqin Liu… in Cell Death & Disease (2022)

Article

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas

Autophagy is an evolutionally conserved catabolic process that degrades cells to maintain homeostasis. Cisplatin-activated autophagy promotes the expression of circ-PKD2, which plays a role as a tumor suppress...

Ling Gao, Qian Zhang, Shaoming Li, **g**g Zheng, Wenhao Ren… in Cell Death & Disease (2022)

Article

Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing

The persistent inflammatory response at the wound site is a cardinal feature of nonhealing wounds. Prolonged neutrophil presence in the wound site due to failed clearance by reduced monocyte-derived macrophage...

Wei Kiat Jonathan Wee, Zun Siong Low, Chin Kiat Ooi… in Cell Death & Disease (2022)

Article

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma

For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing a...

Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang… in Cell Death & Disease (2022)

Article

Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy

Upon vascular injury, vascular smooth muscle cells (VSMCs) change from a contractile phenotype to a synthetic phenotype, thereby leading to atherogenesis and arterial restenosis. Myocardin (MYOCD) is essential...

Danyang Shi, **hua Ding, Shouqiang **e, Lei Huang, Hongmin Zhang… in Cell Death & Disease (2022)

Article

Correction: m⁶A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression

Panpan Zhang, Qiu** He, Yuan Lei, Yingqin Li, **n Wen… in Cell Death & Disease (2022)