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  1. No Access

    Article

    Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

    Fluoroacetate dehalogenases (FAcD), a homodimeric enzyme, catalyzes the conversion of fluoroacetic acid to glycolic acid (GoA). It has been proved that the enzyme has a half-of-the-site reactivity. Namely, its...

    Ke-Wei Chen, Jia-Nan Chen, Jun Zhang, Chao Wang, Tian-Yu Sun in Science China Chemistry (2024)

  2. Article

    Open Access

    The elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice

    Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Develo** high-NUE rice cultivars through balancing nitrogen uptake and the formation...

    Wei Wu, **aoou Dong, Gaoming Chen, Zhixi Lin, Wenchao Chi, Weijie Tang in Nature Genetics (2024)

  3. Article

    Open Access

    BATF promotes tumor progression and association with FDG PET-derived parameters in colorectal cancer

    The purpose of the study was to evaluate the expression and function of basic leucine zipper ATF-like transcription factor (BATF) in colorectal cancer (CRC), and its correlation with 2-deoxy-2[18F]fluoro-d-glucos...

    **a Lu, Jun Liu, Lijuan Feng, Yan Huang, Yanfeng Xu in Journal of Translational Medicine (2024)

  4. No Access

    Article

    T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin

    T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...

    Jun-jun Liu, Zhi-di Pan, Ya-li Yue, Shu-sheng Wang, Jie Chen in Acta Pharmacologica Sinica (2024)

  5. Article

    Open Access

    p-Parabolicity and a Generalized Bochner’s Method with Applications

    The notions of function growth and sharp global integral estimates in p-harmonic geometry in Wei (Contemp Math 756:247–269, 2020) and Wei et al. (Sharp estimates on

    Shihshu Walter Wei, Jun-Fang Li, Lina Wu in La Matematica (2024)

  6. No Access

    Article

    Application of ambient noise tomography to coastal granite islands: A case study of Wuzhizhou Island in Hainan, China

    Islands are valuable land resources in the ocean, and their detailed subsurface seismic velocity structures are highly important for underground space utilization, engineering construction, and geological disa...

    Cheng Huang, Sheng Liu, Jun-Qiao Long, Chang-Rong Zhang, Bo **ao in Applied Geophysics (2024)

  7. Article

    Open Access

    Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans

    Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid redu...

    Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang in Cell Research (2024)

  8. No Access

    Article

    Standard-definition White-light, High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas: A Multicenter Randomized Controlled Trial

    This study aimed to compare the performance of standard-definition white-light endoscopy (SD-WL), high-definition white-light endoscopy (HD-WL), and high-definition narrow-band imaging (HD-NBI) in detecting co...

    Chang-wei Duan, Hui-hong Zhai, Hui **e, **an-zong Ma in Current Medical Science (2024)

  9. No Access

    Article

    The subcommissural organ regulates brain development via secreted peptides

    The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown...

    Tingting Zhang, Daosheng Ai, **li Wei, Ying Xu, Zhanying Bi in Nature Neuroscience (2024)

  10. No Access

    Article

    Comparison of laser cladding properties of tantalum and tantalum pentoxide powders on titanium substrates

    Tantalum (Ta) has excellent mechanical properties, biocompatibility, and corrosion resistance. However, its application is limited by its high cost. Tantalum pentoxide (Ta2O5), a stable oxide of Ta, is a key role...

    Yi-Ju Li, Yueh-Hung Hsieh, Wei-Ting Lin in The International Journal of Advanced Manu… (2024)

  11. No Access

    Article

    Enhanced Catalytic Performance and Poison Resistance of Cu–Mn–Ce Ternary Mixed Oxide for Chlorobenzene Oxidation

    Cu–Mn–Ce ternary mixed oxides, prepared via the citric acid complex method and supported on cordierite, were investigated for their catalytic activity in the oxidation of chlorobenzene. The impact of various r...

    **n Li, Ming-yang Gu, Guo-fang An, Chen Wei, Jun-jie Mao, Qiong Huang in Catalysis Letters (2024)

  12. No Access

    Article

    The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy

    As the range of applications for molybdenum and its alloys has expanded, the corrosive environment for molybdenum alloys has become more demanding. In the past, the content of do** elements has been studied ...

    Song-Wei Ge, ** Hu, Jie Deng, Shi-Lei Li, Hai-Rui **ng, Jia-Yu Han in Tungsten (2024)

  13. Article

    Open Access

    Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma

    Intrahepatic cholangiocarcinoma (ICCA) is a heterogeneous group of malignant tumors characterized by high recurrence rate and poor prognosis. Heterochromatin Protein 1α (HP1α) is one of the most important nonh...

    Fei **ong, Da Wang, Wei **ong, **n Wang in Journal of Experimental & Clinical Cancer … (2024)

  14. Article

    Open Access

    Search for a third-generation leptoquark coupled to a τ lepton and a b quark through single, pair, and nonresonant production in proton-proton collisions at \( \sqrt{s} \) = 13 TeV

    A search is presented for a third-generation leptoquark (LQ) coupled exclusively to a τ lepton and a b quark. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded w...

    A. Hayrapetyan, A. Tumasyan, W. Adam, J. W. Andrejkovic in Journal of High Energy Physics (2024)

  15. Article

    Open Access

    A dimension-aware gaining-sharing knowledge algorithm for distributed hybrid flowshop scheduling with resource-dependent processing time

    The resource-assisted processing operation involves the coupling of multi-dimensional sub-problem, which poses a challenge in scheduling system. In this study, a dimension-aware gain-sharing knowledge algorith...

    Rong-hao Li, Jun-qing Li, Jia-ke Li, Wei Ouyang in Complex & Intelligent Systems (2024)

  16. Article

    Open Access

    Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

    Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...

    Liu-** Chu, Wen-Jia Wang, **n-Pei Gu, ** Wu, Chen Gao in Military Medical Research (2024)

  17. No Access

    Article

    A Diffraction Effect Investigation for the Solar Irradiance Absolute Radiometer on the Fengyun-3F Satellite

    The measurements of the Total Solar Irradiance (TSI) is a primary means to investigate solar activity and key measurement for understanding global climate change. The aperture diffraction is an error factor fo...

    Hang Dong, **aolong Yi, Peng Zhang, Dongjun Yang, Yuchen Lin, ** Qi in Solar Physics (2024)

  18. No Access

    Article

    Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator

    The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...

    Yang Zhang, Sheng-Quan Yan, Ming He, Qing-Zhang Zhao in Nuclear Science and Techniques (2024)

  19. Article

    Open Access

    Mullerian adenosarcoma of the uterus with MASO: a case report of cervical adenosarcoma in a young female that never had sexual behavior

    Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy i...

    Jia-Wei Chen, Ya-Jie Huang, Ling-Lu Wang, Jun-Jiang Liu, Ming-Mei Shi in BMC Women's Health (2024)

  20. Article

    Open Access

    Preoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial

    The purpose of this study was to evaluate the safety and efficacy of preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by compre...

    Wen-Yang Liu, Yuan Tang, Ning Li, Yu Tang, Yun-Jie Cheng, Lin Yang in BMC Geriatrics (2024)

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