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2,903 Result(s)
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Article
Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase
Fluoroacetate dehalogenases (FAcD), a homodimeric enzyme, catalyzes the conversion of fluoroacetic acid to glycolic acid (GoA). It has been proved that the enzyme has a half-of-the-site reactivity. Namely, its...
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Open AccessThe elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice
Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Develo** high-NUE rice cultivars through balancing nitrogen uptake and the formation...
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Open AccessBATF promotes tumor progression and association with FDG PET-derived parameters in colorectal cancer
The purpose of the study was to evaluate the expression and function of basic leucine zipper ATF-like transcription factor (BATF) in colorectal cancer (CRC), and its correlation with 2-deoxy-2[18F]fluoro-d-glucos...
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T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...
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Open Accessp-Parabolicity and a Generalized Bochner’s Method with Applications
The notions of function growth and sharp global integral estimates in p-harmonic geometry in Wei (Contemp Math 756:247–269, 2020) and Wei et al. (Sharp estimates on
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Article
Application of ambient noise tomography to coastal granite islands: A case study of Wuzhizhou Island in Hainan, China
Islands are valuable land resources in the ocean, and their detailed subsurface seismic velocity structures are highly important for underground space utilization, engineering construction, and geological disa...
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Open AccessTargeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid redu...
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Standard-definition White-light, High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas: A Multicenter Randomized Controlled Trial
This study aimed to compare the performance of standard-definition white-light endoscopy (SD-WL), high-definition white-light endoscopy (HD-WL), and high-definition narrow-band imaging (HD-NBI) in detecting co...
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Article
The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown...
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Article
Comparison of laser cladding properties of tantalum and tantalum pentoxide powders on titanium substrates
Tantalum (Ta) has excellent mechanical properties, biocompatibility, and corrosion resistance. However, its application is limited by its high cost. Tantalum pentoxide (Ta2O5), a stable oxide of Ta, is a key role...
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Article
Enhanced Catalytic Performance and Poison Resistance of Cu–Mn–Ce Ternary Mixed Oxide for Chlorobenzene Oxidation
Cu–Mn–Ce ternary mixed oxides, prepared via the citric acid complex method and supported on cordierite, were investigated for their catalytic activity in the oxidation of chlorobenzene. The impact of various r...
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The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy
As the range of applications for molybdenum and its alloys has expanded, the corrosive environment for molybdenum alloys has become more demanding. In the past, the content of do** elements has been studied ...
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Open AccessUnveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICCA) is a heterogeneous group of malignant tumors characterized by high recurrence rate and poor prognosis. Heterochromatin Protein 1α (HP1α) is one of the most important nonh...
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Open AccessSearch for a third-generation leptoquark coupled to a τ lepton and a b quark through single, pair, and nonresonant production in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search is presented for a third-generation leptoquark (LQ) coupled exclusively to a τ lepton and a b quark. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV recorded w...
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Open AccessA dimension-aware gaining-sharing knowledge algorithm for distributed hybrid flowshop scheduling with resource-dependent processing time
The resource-assisted processing operation involves the coupling of multi-dimensional sub-problem, which poses a challenge in scheduling system. In this study, a dimension-aware gain-sharing knowledge algorith...
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Article
Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
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Article
A Diffraction Effect Investigation for the Solar Irradiance Absolute Radiometer on the Fengyun-3F Satellite
The measurements of the Total Solar Irradiance (TSI) is a primary means to investigate solar activity and key measurement for understanding global climate change. The aperture diffraction is an error factor fo...
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Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae. Lunar samples retain valuable information from these events, via detectable long-lived “fingerprint” rad...
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Open AccessMullerian adenosarcoma of the uterus with MASO: a case report of cervical adenosarcoma in a young female that never had sexual behavior
Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy i...
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Open AccessPreoperative chemoradiotherapy in older patients with rectal cancer guided by comprehensive geriatric assessment within a multidisciplinary team—a multicenter phase II trial
The purpose of this study was to evaluate the safety and efficacy of preoperative concurrent chemoradiotherapy (preCRT) for locally advanced rectal cancer in older people who were classified as “fit” by compre...