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Article
ASIP genetic variants and the number of non-melanoma skin cancers
Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women w...
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Article
Genetic variants in telomere-maintaining genes and skin cancer risk
Telomere-related genes play an important role in maintaining the integrity of the telomeric structure that protects chromosome ends, and telomere dysfunction may lead to tumorigenesis. We evaluated the associa...
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Article
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk
Mistakes in DNA repair can result in sustained damage and genetic instability. We comprehensively evaluated common variants in DNA repair pathway genes for their association with postmenopausal breast cancer r...
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Article
Open AccessGenetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...
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Article
Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk
Purpose We comprehensively evaluated genetic variants in DNA repair genes with premenopausal breast cancer risk. Methods In this nested case–control study of 239 prospectively ascertained premenopausal breast can...
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Article
A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator ...
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Article
A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk
Oxidative stress may be involved in breast carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). A single nucleotide polymorphism (SNP) G-463A in t...
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Article
Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)
We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk.