131 Result(s)

Article

Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine

Hui Zhao, Na-Na Zhang, Suad Hannawi, Ai-Ru Zhu, **ao-Chuan **ong… in Cell Discovery (2024)

Article

SH3RF2 contributes to cisplatin resistance in ovarian cancer cells by promoting RBPMS degradation

Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy f...

Ting-Ting Gong, Fang-Hua Liu, Qian **ao, Yi-Zi Li, Yi-Fan Wei… in Communications Biology (2024)

Article

Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer is unknown. CEP inhibited the cellula...

Yang-yang Lu, Chun-yang Zhu, Yi-xin Ding, Bing Wang, Shu-fen Zhao… in Cell Death Discovery (2023)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics

Glioma stem cells (GSCs) are responsible for glioma recurrence and drug resistance, yet the mechanisms underlying their maintenance remains unclear. This study aimed to identify enhancer-controlled genes invol...

Yu-meng Sun, Yi-meng Zhang, Hai-liang Shi, Song Yang, Yin-long Zhao… in Hereditas (2023)

Article

Phylogeography of cultivated and wild ophiopogon japonicus based on chloroplast DNA: exploration of the origin and sustainable cultivation

Ophiopogon japonicus, mainly planted in Sichuan (CMD) and Zhejiang (ZMD) province in China, has a lengthy cultivation history. During the long period of domestication, the genetic diversity of cultivated O. japon...

Lu-ying Zhao, Yu-ling Liu, Yi Shen, Qiao-yan Zhang, Sha Liu… in BMC Plant Biology (2023)

Article

A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Bone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in lung cancer patients. However, the regulatory mechanisms under...

Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang… in Cell Death & Disease (2023)

Article

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria

Only a small proportion of patients with triple-negative breast cancer benefit from immune checkpoint inhibitor (ICI) targeting PD-1/PD-L1 signaling in combination with chemotherapy. Here, we discovered that t...

**ao-Qing **e, Yi Yang, Qiang Wang, Hao-Fei Liu, Xuan-Yu Fang… in Cell Research (2023)

Article

Drug repurposing strategy II: from approved drugs to agri-fungicide leads

Epidemic diseases of crops caused by fungi deeply affected the course of human history and processed a major restriction on social and economic development. However, with the enormous misuse of existing antimi...

Jun-**a An, Yue Ma, Wen-Bin Zhao, Yong-Mei Hu, Yi-Rong Wang… in The Journal of Antibiotics (2023)

Article

Identification of matrix-remodeling associated 5 as a possible molecular oncotarget of pancreatic cancer

Pancreatic cancer has an extremely poor prognosis. Here we examined expression, potential functions and underlying mechanisms of MXRA5 (matrix remodeling associated 5) in pancreatic cancer. Bioinformatics stud...

Shi-qing Peng, **ao-ren Zhu, Ming-zhi Zhao, Yi-fan Zhang… in Cell Death & Disease (2023)

Article

NMDARs antagonist MK801 suppresses LPS-induced apoptosis and mitochondrial dysfunction by regulating subunits of NMDARs via the CaM/CaMKII/ERK pathway

Lipopolysaccharide (LPS) displays a robust immunostimulatory ability upon Toll-like receptor 4 (TLR4) recognition. N-methyl-D-aspartate receptors (NMDARs) are highly compartmentalized in most cells and implica...

Wei-Min Han, **ao-Bin Hao, Yi-**ang Hong, Shan-Shan Zhao… in Cell Death Discovery (2023)

Article

Analysis of Whole Blood and Urine Trace Elements in Children with Autism Spectrum Disorders and Autistic Behaviors

The relationship between trace elements and neurological development is an emerging research focus. We performed a case–control study to explore (1) the differences of 13 trace elements chromium (Cr), manganes...

Gang Zhao, Si-** Liu, **n-yu Gan, Jun-ru Li… in Biological Trace Element Research (2023)

Article

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics

Effective phosphoproteome of nanoscale sample analysis remains a daunting task, primarily due to significant sample loss associated with non-specific surface adsorption during enrichment of low stoichiometric ...

Chia-Feng Tsai, Yi-Ting Wang, Chuan-Chih Hsu, Reta Birhanu Kitata… in Communications Biology (2023)

Article

Drug repurposing strategy part 1: from approved drugs to agri-bactericides leads

Phytopathogenic bacteria are a major cause of crop mortality and yield reduction, especially in field cultivation. The lack of effective chemistry agri-bactericides is responsible for challenging field prevent...

Yue Ma, Yi-Rong Wang, Ying-Hui He, Yan-Yan Ding, Jun-**a An… in The Journal of Antibiotics (2023)

Article

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka… in Genome Biology (2022)

Article

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly exp...

Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu… in Cell Research (2022)

Article

RLFDDA: a meta-path based graph representation learning model for drug–disease association prediction

Drug repositioning is a very important task that provides critical information for exploring the potential efficacy of drugs. Yet develo** computational models that can effectively predict drug–disease assoc...

Meng-Long Zhang, Bo-Wei Zhao, **ao-Rui Su, Yi-Zhou He, Yue Yang… in BMC Bioinformatics (2022)

Article

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...

Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, **n-**n Guo, Yun-Lu Li… in Cell Discovery (2022)

Article

Identification of serum metabolites enhancing inflammatory responses in COVID-19

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a strong production of inflammatory cytokines such as TNF and IL-6, which underl...

Chen-Song Zhang, Bingchang Zhang, Mengqi Li, **aoyan Wei… in Science China Life Sciences (2022)

Article

TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma

TAR DNA-Binding Protein 43 (TDP-43) has been well studied in neurodegenerative diseases, but its potential role in malignance is still unclear. Here, we demonstrate that TDP-43 contributes to the suppression o...

Bo-wen Liu, **ang-yun Wang, **-ling Cao, Lu-lu Chen, Yi-lei Wang… in Communications Biology (2022)