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Xueqin **a
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Article
Effect of WC-10Co-4Cr Reinforcement Amount on Wear and Corrosion Resistance of Fe-Based Amorphous Coatings
WC-10Co-4Cr/Fe-based amorphous composite coatings with different WC-10Co-4Cr powder contents (0-12 wt.%) were prepared on C45 steel by plasma spraying. The microstructure, hardness, wear resistance and corrosi...
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Open AccessIntelligent conflict detection of IoT services using high-level Petri nets
Internet of Things has become a common paradigm for various domains. To meet a user’s complex requirement, we should compose multiple IoT devices (IoT services) to provide comprehensive services to the user. H...
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Divergent intra- and interspecific root order variability identifies a two-dimensional root economics spectrum
The form-function linkages and variation of fine root traits reflect adaptive strategies to cope with complex soil environments. However, their contributions to the root economics spectrum (RES) remain unclear.
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Aluminum particle agglomeration mechanism and microscopic combustion characteristics of NEPE propellants
Since solid propellants can significantly increase the mobility, load, and range of missile weapons and equipment when used as a power source, energy performance is always the primary focus of solid propulsion...
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Acute Pancreatitis in Pregnancy: A Propensity Score Matching Analysis and Dynamic Nomogram for Risk Assessment
Acute pancreatitis is easily confused with abdominal pain symptoms, and it could lead to serious complications for pregnant women and fetus, the mortality was as high as 3.3% and 11.6–18.7%, respectively. Howe...
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Open AccessStructural basis for human Cav3.2 inhibition by selective antagonists
The Cav3.2 subtype of T-type calcium channels has been targeted for develo** analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM structures of Cav3.2 alone and in compl...
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Evaluation of the JF5-based Aspergillus galactomannoprotein lateral flow device for diagnosing invasive aspergillosis in cancer patients
Cancer patients are at heightened risk for invasive aspergillosis (IA), a condition associated with elevated mortality risk. The JF5-based Aspergillus Galactomannoprotein Lateral Flow Device (AspLFD) offers rapid...
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Long-term, observational, real-world study of dupilumab for the treatment of moderate-to-severe atopic dermatitis: a 52-week single-center retrospective analysis in China
For dupilumab, real-world long-term follow-up data remain scarce, and studies on optimized treatment modes as well as drug survival rate and its predictors are lacking. To explore the effectiveness of differen...
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Article
Metabolic engineering of Bacillus subtilis for de novo synthesis of 6′-sialyllactose
6′-sialyllactose (6′-SL) is an important component of human milk oligosaccharides (HMOs) and has numerous infant health benefits. The construction of efficient and food-safe microbial cell factories to produce 6′
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Open AccessRevisiting the role of pregnancy zone protein (PZP) as a cancer biomarker in the immunotherapy era
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Open AccessRutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP
Ensartinib, an approved ALK inhibitor, is used as a first-line therapy for advanced ALK-positive non-small cell lung cancer in China. However, the hepatotoxicity of ensartinib seriously limits its clinical app...
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Article
AlphaLISA-Based Immunoassay for Detection of Troponin T in Serum of Patients with Acute Myocardial Infarction
Survival and prognosis of patients with acute myocardial infarction (AMI) are highly dependent on rapid and accurate diagnosis of myocardial damage. Troponin T is the primary diagnostic biomarker and is widely...
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Open AccessTargeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer
Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic eff...
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Open AccessNeutrophils in Cancer immunotherapy: friends or foes?
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matri...
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Expanding the genetic and phenotypic relevance of CLCN4 variants in neurodevelopmental condition: 13 new patients
CLCN4 variations have recently been identified as a genetic cause of X-linked neurodevelopmental disorders. This study aims to broaden the phenotypic spectrum of CLCN4-related condition and correlate it with func...
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Open AccessThe miR-641-STIM1 and SATB1 axes play important roles in the regulation of the Th17/Treg balance in ITP
Immune thrombocytopenia (ITP) is an autoimmune disease caused by T-cell dysfunction. Recently, several studies have shown that a disturbed Th17/Treg balance contributes to the development of ITP. MicroRNAs (mi...
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Open AccessRecurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
The absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a chromosome, which may cause human genetic disorders. However, no method of l...
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Open AccessEnhancing multiple myeloma staging: a novel cell death risk model approach
The prognostication of survival trajectories in multiple myeloma (MM) patients presents a substantial clinical challenge. Leveraging transcriptomic and clinical profiles from an expansive cohort of 2,088 MM pa...
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Open AccessBattling Salmonella enteritidis infections: integrating proteomics and in vivo assessment of Galla Chinensis tannic acid
Salmonella infections pose a significant threat to animal and human health. Phytochemicals present a potential alternative treatment. Galla chinensis tannic acid (GCTA), a hydrolyzable polyphenolic compound, inhi...
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Open AccessIdentification and characterization of whole blood gene expression and splicing quantitative trait loci during early to mid-lactation of dairy cattle
Characterization of regulatory variants (e.g., gene expression quantitative trait loci, eQTL; gene splicing QTL, sQTL) is crucial for biologically interpreting molecular mechanisms underlying loci associated w...
