11th Annual meeting of the EBMT
European Cooperative Group for Bone Marrow Transplantation
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Article
Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation
We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet...
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Chapter and Conference Paper
Erythrocytosis in Renal Graft Recipients
Anemia develops during the course of chronic renal failure with deterioration of excretory kidney function [1–3]. Erythropoietin (EPO) deficiency [1, 2] and uremic bone marrow intoxication [4, 5] have been imp...
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Article
Identification of activated T cells and the suppressor/inducer subset in patients suffering from severe aplastic anemia
In patients with severe aplastic anemia (SAA), lymphocyte subpopulations were examined for the presence of HLA-DR and 2H4 (suppressor/inducer subset) antigen-expressing cells by flow cytometric analysis. Inves...
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Article
Deficiency of pluripotent hemopoietic progenitor cells in myelodysplastic syndromes
Pluripotent (CFU-MIX), erythroid (BFU-E) and granulocyte/macrophage (CFU-GM) progenitor cells were examined in bone marrow (BM) from 23 patients with myelodysplastic syndromes (MDS). Patients were grouped acco...
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Article
Survival and quality of life in 23 patients with severe aplastic anemia treated with bone marrow transplantation (BMT)
Survival and quality of life are reported in 23 pretransfused patients with severe aplastic anemia (SAA) who underwent bone marrow transplantation (BMT). The projected survival is 76% with 18 of 23 patients be...
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Article
Cytogenetic studies in bone marrow transplant recipients
Chromosome studies were performed in 24 patients who underwent allogeneic bone marrow transplantation (BMT) for severe aplastic anaemia (8), chronic myeloid leukemia (5 in chronic, 2 in accelerated phase and 1...
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Article
Book reviews
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Book
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Chapter
Acquired Deficiency of Fibrinogen (Fbg) and Factor VII (F VII) During and Following Immunosuppression for Severe Aplastic Anemia (SAA) with Antithymocyte Globulin (ATG) and High-Dose Methylprednisolone (MP)
While determing clotting and fibrinolysis proteins by conventional laboratory test kits before, during and after ATG/MP treatment we found a yet undescribed reversible deficiency of Fbg and F VII.
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Chapter
Bone Marrow Transplantation (BMT) for Severe Aplastic Anemia (SAA): Results Obtained in 19 Patients
10 adult patients and 9 children with SAA underwent allogeneic (17) or syngeneic (2) BMT. The median age was 17 years (range 4–37),all patients were pretransfused with a median of 7 units of red blood cells (r...
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Chapter
Patients with Aplastic Anemia Frequently are Histocompatible (HLA-DR, MLC) with Their Mothers
The real cause of Aplastic Anemia (AA) still is unknown. Some imbalances in the distribution of the HLA-antigens, however, have been reported in families of AA patients (1) (2), but none of them definitely cou...
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Chapter
Neopterin Levels in Serum After Bone Marrow Transplantation are Possibly Helpful to Estimate the Activity of Graft-Versus-Host-Disease
Neopterin, (Npt,6-1’,2’,3’-D-erythrotrihydroxy)propy-pteridin) is formed from Guanosine-Triphosphate during the biosynthesis of Tetra-hydrobiopterine, a co-factor of aromatic hydroxylation. The biological func...
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Chapter
Improvement of Severe Aplastic Anemia (SAA) Following Treatment with Cyclosporin-A (CY-A) After Failure of Antithymocyte Globulin (ATG) and High-Dose Methylprednisolone (MP)
A 42 a female with a 2 years history of AA deteriorated to transfusion dependency and was admitted for combined immunosuppresn (IS).Blood counts before IS were:Red cells 2.9 × 1012 /1 (posttr lsfusion value Retic...
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Chapter
Circulating Stem Cells in Patients with Akute Leukaemia in Remission
The results of allogeneic bone marrow transplantation in patients with acute leukaemia (AL) in complete remission (CR) suggest, that supralethal chemo-radiotherapy is capable of eradicating leukaemia. However,...
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Chapter
Ocular Manifestations of Graft-Versus-Host Disease Following Bone Marrow Transplantation
Graft-versus-host disease (GVHD) is a major complication following allogeneic bone marrow transplantation (BMT) and occurs in 50–70% of the patients (1,2). It may begin weeks (acute GVHD) or months (chronic GV...
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Chapter
Buffy Coat Collection and Incubation with a Cytotoxic Compound (ASTA Z 7557) in Patients with Previously Untreated Chronic Granulocytic Leukemia (CGL)
Conventional treatment with cytostatics and/or irradiation can barely prolong survival in patients with CML.Allogeneic BMT has frequently led to Philadelphia (Ph)-negative haemopoiesis with the option of long ...
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Chapter
Megakaryocytopoiesis Stimulating Factors are Highly Increased in Sera from Patients After Bone Marrow Transplantation
The relative roles of various humoral factors on megakaryocytopoiesis in man remain still unclear. However, in vivo and in vitro studies support a bi-level regulation of megakaryocyte formation. Hoffman et al....
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Chapter
Failure of Identical Twin Bone Marrow to Restore Haemopoiesis in 2 Patients with Severe Aplastic Anemia (SAA) without Immunosuppressive (IS) Conditioning
The role of mononuclear cells (MNC) in the regulation of aplastic haemopoiesis is poorly understood.Evidence for an important role of T-lymphocytes in SAA is strengthened by a frequent clinical response after ...
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Chapter
Attempt for a Complete Protocol of TBI
As the dose inside tissue is strongly dependent on the density of the desired object, every patient is scanned in 8 planes on the CT. In the following the calculation of lung dose is done by a treatment planni...
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Chapter
HLA-DR Expression by Keratinocytes in Acute Cutaneous Graft-Versus-Host Disease
The emergence of acute graft-versus-host disease (GvHD) is a potentially life-threatening complication in patients receiving allogeneic bone marrow transplantation (BMT) and therefore requires accurate diagnos...
