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Article
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life
Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities during development and early adulthood, but had a reduced lifespan and increased incidence of neoplastic changes in the liver...
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Article
Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model
Previous studies in our laboratories demonstrated that overexpression of manganese superoxide dismutase (MnSOD) suppressed both the incidence and multiplicity of papillomas in a DMBA/TPA multi-stage skin carci...
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Article
Genetic Dissection of Region Associated with Behavioral Abnormalities in Mouse Models for Down Syndrome
Two animal models of Down syndrome (human trisomy 21) with segmental trisomy for all (Ts65Dn) or part (Ts1Cje) of human chromosome 21-homologous region of mouse chromosome 16 have cognitive and behavioral abno...
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Article
Genetic modification of the dilated cardiomyopathy and neonatal lethality phenotype of mice lacking manganese superoxide dismutase
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Article
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, w...
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Mouse Models of Human Trisomy 21 (Down Syndrome)
Trisomy 21 is one of the most frequent chomosome abnormalities in man. One out of 700 to 1000 newborn babies has this chromosomal imbalance, which arises due to meiotic nondisjunction of chromosome 21. This le...
