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Article
Open AccessImplantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization
Approximately 6.3 million fractures occur in the U.S. annually, with 5–10% resulting in debilitating nonunions. A major limitation to achieving successful bony union is impaired neovascularization. To augment ...
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Article
Risk factors and consequences of conversion to open surgery in laparoscopic common bile duct exploration
Although laparoscopic common bile duct exploration (LCBDE) has shown many obvious advantages compared with open surgery in the treatment of common bile duct (CBD) stones, it remains unclear regarding risk fact...
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Article
Open AccessCorrection to: miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a
The original article [1] contains an error in Fig. 5a whereby the Western blot bands representing CyclinD1 have mistakenly been duplicated over the Western blot bands intended to represent SGK.
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Article
Open AccessmiR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a
High frequency of recurrence is the major cause of the poor outcomes for patients with hepatocellular carcinoma (HCC). microRNA (miR)-182-5p emerged as a high-priority miRNA in HCC and was found to be related ...
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Article
Surgery for Duodenal Gastrointestinal Stromal Tumors: A Single-Center Experience
The duodenal gastrointestinal stromal tumors (GISTs) are an extremely rare subset of GISTs. The optimal surgical procedure remains not well defined.
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Article
Low-temperature synthesis of zircon by soft mechano–chemical activation-assisted sol–gel method
Zircon (i.e., ZrSiO4) was synthesized by a sol–gel route at a low temperature with assistance of soft mechano–chemical activation of derived precursors in a high-energy density stirred bead mill. The reaction of ...
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Article
Five hundred consecutive laparoscopic common bile duct explorations: 5-year experience at a single institution
Laparoscopic common bile duct exploration (LCBDE) has gained wide popularity in the treatment of choledocholithiasis. Bile leakage remains a major cause of postoperative morbidity. The aim of this study was to...
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Article
Intratracheal Administration of Hyaluronan-Cisplatin Conjugate Nanoparticles Significantly Attenuates Lung Cancer Growth in Mice
To determine aerosol administration capability and therapeutic efficacy of the new formulation of hyaluronan cisplatin conjugates, HylaPlat™ (HA-Pt), for lung cancer treatment.
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Article
Open AccessMetformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models
Sorafenib is recognized as a standard treatment for advanced hepatocellular carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the use of sorafenib because of side effects. In ad...
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Article
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
Modulating cholesterol metabolism can improve CD8+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane chol...
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Article
HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma
Overexpression of CUB domain-containing protein 1 (CDCP1), a transmembrane glycoprotein and major substrate of Src family kinases (SFKs), always indicates unfavorable outcomes in various cancers. The character...
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Article
Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway
As a glycol-protein located in extracellular matrix (ECM), tenascin-C (TNC) is absent in most normal adult tissues but is highly expressed in the majority of malignant solid tumors. Pancreatic cancer is charac...
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Article
Adjuvant sorafenib therapy in patients with resected hepatocellular carcinoma: evaluation of predictive factors
Currently there is no predictor for survival after adjuvant sorafenib in patients with hepatocellular carcinoma (HCC) who have undergone curative resection. Thirty-eight patients who underwent curative resect...
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Article
A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population
Autism spectrum disorder (ASD) is one of neurodevelopmental disorders with highly heritability. Recently, abnormality at the synapse is found to be important etiology of ASD. SHANK3 gene is suggested as a strong ...
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Article
Open AccessGenetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis
Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inact...
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Article
Designing an integrated logistics network in a supply chain system
Many companies spend significant amounts of money and time on reverse logistics which mainly deal with transporting and handling returned products. Therefore, efficient management of return products is an urge...
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Article
The prognostic analysis of clinical breast cancer subtypes among patients with liver metastases from breast cancer
To determine whether the inferior outcome noted with triple-negative breast cancer (TNBC) reflects a higher risk population among patients with breast cancer liver metastases.
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Article
A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis
Kawasaki disease (KD) is a multi-systemic vasculitis which preferentially affects infants and children. A single nucleotide polymorphism (rs28493229) in the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) was ide...
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Article
Treatment outcome of patients with liver-only metastases from breast cancer after mastectomy: a retrospective analysis
To evaluate the efficiency of combined treatment of transcatheter arterial chemoembolization (TACE) and systemic chemotherapy (SC) for liver-only metastases from breast cancer after mastectomy.
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Article
Sorafenib combined with cryoablation to treat unresectable hepatocellular carcinoma
To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma (HCC).
