49 Result(s)
-
Article
Immunoassay and Nb2 lymphoma bioassay prolactin levels and mammographic density in premenopausal and postmenopausal women the Nurses’ Health Studies
Higher circulating prolactin levels have been associated with higher percent mammographic density among postmenopausal women in some, but not all studies. However, few studies have examined associations with d...
-
Article
The Association of Reproductive and Lifestyle Factors with a Score of Multiple Endogenous Hormones
We recently reported that high levels of multiple sex and growth hormones were associated with increased postmenopausal breast cancer risk. Limited research has explored the relationship between reproductive, ...
-
Article
Open AccessPlasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study
Moderate to severe premenstrual syndrome (PMS) affects 8–20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk. However, vitamin D status is influenced ...
-
Article
Digoxin use and risk of invasive breast cancer: evidence from the Nurses’ Health Study and meta-analysis
Despite preclinical evidence supporting anti-cancer effects of cardiac glycosides, epidemiologic studies consistently show elevated breast cancer risk in digoxin users. We studied this association in the Nurs...
-
Article
Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women
Analgesic use has been hypothesized to reduce the risk of some cancers, with inverse associations between analgesics and colon cancer, and suggestive inverse associations for breast cancer. Estrogen metabolite...
-
Article
Updates from the Editors
-
Article
Beta blockers and angiotensin-converting enzyme inhibitors’ purported benefit on breast cancer survival may be explained by aspirin use
Preclinical and epidemiologic evidence supports a possible role for beta-adrenergic blocking drugs (beta-blockers), and angiotensin-converting enzyme inhibitors (ACEIs) in promoting survival after breast cance...
-
Article
Plasma enterolactone and breast cancer risk in the Nurses’ Health Study II
Lignans are plant-based phytoestrogens with both estrogenic and anti-estrogenic properties that may be important for breast carcinogenesis. Retrospective studies have observed decreased breast cancer risk asso...
-
Article
Radial scars and subsequent breast cancer risk: results from the Nurses’ Health Studies
Radial scars (RS) are benign proliferative lesions associated with an increased risk of subsequent breast cancer. However, it remains unclear whether RS are an independent risk factor for breast cancer or whet...
-
Article
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women
In previous studies of postmenopausal women, overall intake of fruits and vegetables groups has been inversely associated with estrogen receptor-negative (ER−) breast cancer. In this analysis, we prospectively...
-
Article
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication
Menopausal hormone therapy (MHT) is associated with an elevated risk of breast cancer in postmenopausal women. To identify genetic loci that modify breast cancer risk related to MHT use in postmenopausal women...
-
Article
Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up
Plasma estrogen and androgen levels are positively associated with postmenopausal breast cancer risk, but how long a single blood measurement can predict risk and whether the associations vary by tumor hormone...
-
Article
Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, growth hormone, and mammographic density in the Nurses’ Health Studies
Higher circulating insulin-like growth factor I (IGF-1) levels have been associated with higher mammographic density among women in some, but not all studies. Also, few studies have examined the association be...
-
Article
Body Size in Relation to Urinary Estrogens and Estrogen Metabolites (EM) Among Premenopausal Women during the Luteal Phase
Estrogen metabolism profiles may play an important role in the relationship between body size and breast carcinogenesis. Previously, we observed inverse associations between current body mass index (BMI) and p...
-
Article
Urinary estrogens and estrogen metabolites and mammographic density in premenopausal women
Mammographic density is a strong and independent risk factor for breast cancer and is considered an intermediate marker of risk. The major predictors of premenopausal mammographic density, however, have yet to...
-
Article
Open AccessGenetic variability in IGF-1 and IGFBP-3 and body size in early life
Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previ...
-
Article
Family history and risk of breast cancer: nurses’ health study
Family history of cancer remains underused in general clinical practice. We assess age at diagnosis and the role of family history in risk of breast cancer. Prospective follow-up of nurses’ health study partic...
-
Article
A dietary pattern derived to correlate with estrogens and risk of postmenopausal breast cancer
Circulating estrogens are an established risk factor for breast cancer and some data suggest that diet may influence estrogen levels. Therefore, using a subsample (n = 550) of women from a large cohort, we applie...
-
Article
Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer
At least four major categories of invasive breast cancer have been reproducibly identified by gene expression profiling: luminal A, luminal B, HER2-type, and basal-like. These subtypes have been shown to diff...
-
Article
COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin
Some previous studies have found worse prognosis among cyclooxygenase-2 (COX-2)-expressing breast cancers. Aspirin and NSAIDs inhibit COX-2. Three studies, including ours, have reported a survival advantage am...
