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Article
Sex differences in antidepressant efficacy
Sex differences have been observed across many psychiatric diseases, especially mood disorders. For major depression, the most prevalent psychiatric disorder, females show a roughly two-fold greater risk as co...
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Article
Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
Reward drives motivated behaviours and is essential for survival, and therefore there is strong evolutionary pressure to retain contextual information about rewarding stimuli. This drive may be abnormally stro...
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Article
Venous invasion by hepatic tumors: imaging appearance and implications for management
Venous invasion by hepatic tumors most commonly occurs with hepatocellular carcinoma and is associated with worse patient prognosis. Imaging plays an important role in the diagnosis of tumor thrombus in the li...
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Hepatic tumors of vascular origin: imaging appearances
A number of benign and malignant neoplasms may arise from the vascular elements within the liver parenchyma. Lesions discussed in this article include angiosarcoma, epithelioid hemangioendothelioma, solitary f...
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Article
Safety and Effectiveness of Palliative Tunneled Peritoneal Drainage Catheters in the Management of Refractory Malignant and Non-malignant Ascites
To determine the safety and effectiveness of tunneled peritoneal catheters in the management of refractory malignant and non-malignant ascites.
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Article
Convergent Mechanisms Underlying Rapid Antidepressant Action
Traditional pharmacological treatments for depression have a delayed therapeutic onset, ranging from several weeks to months, and there is a high percentage of individuals who never respond to treatment. In co...
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Article
Microstructure, Fatigue Behavior, and Failure Mechanisms of Direct Laser-Deposited Inconel 718
Inconel 718 is considered to be a superalloy with a series of superior properties such as high strength, creep resistance, and corrosion resistance at room and elevated temperatures. Additive manufacturing (A...
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MRI-guided Wire Localization Surgical Biopsy in an Adolescent Patient with a Difficult to Diagnose Case of Lymphoma
A 17-year-old previously healthy female presented with a progressive soft tissue infiltrative process involving the neck and thorax. Extensive diagnostic evaluation including multiple imaging, laboratory, and ...
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Selective Parathyroid Hormone Venous Sampling in Patients with Persistent or Recurrent Primary Hyperparathyroidism and Negative, Equivocal or Discordant Noninvasive Imaging
In patients with persistent (P-PHPT) or recurrent (R-PHPT) primary hyperparathyroidism, preoperative localization is important. Selective parathyroid hormone venous sampling (sPVS) is an invasive technique tha...
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Article
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous monoaminergic-based antidepressants, most patients require severa...
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Article
Understanding the Microstructure Formation of Ti-6Al-4V During Direct Laser Deposition via In-Situ Thermal Monitoring
Understanding the thermal phenomena associated with direct laser deposition (DLD) is an important step toward obtaining ‘process–property–performance’ relationships for various designed parts and materials, as...
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Initial Results of Image-Guided Percutaneous Ablation as Second-Line Treatment for Symptomatic Vascular Anomalies
The purpose of this study was to determine the feasibility, safety, and early effectiveness of percutaneous image-guided ablation as second-line treatment for symptomatic soft-tissue vascular anomalies (VA).
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Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve sympto...
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Article
Mechanical Properties and Microstructural Features of Direct Laser-Deposited Ti-6Al-4V
Direct laser deposition (DLD) is a means to additively manufacture metallic, functional parts via blown powder (or wire) and in situ laser delivery. Despite the various research efforts in characterization of ...
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Role for Putative Hepatocellular Carcinoma Stem Cell Subpopulations in Biological Response to Incomplete Thermal Ablation: In Vitro and In Vivo Pilot Study
To investigate the potential role for CD44+ and CD90+ hepatocellular carcinoma (HCC) cellular subpopulations in biological response to thermal ablation-induced heat stress.
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Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression
The authors find that serotonin, acting through 5-HT1B receptors, potentiates temporoammonic pathway–to–CA1 cell excitatory synapses in the hippocampus. Chronic unpredictable stress increased the magnitude of thi...
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AS30D Model of Hepatocellular Carcinoma: Tumorigenicity and Preliminary Characterization by Imaging, Histopathology, and Immunohistochemistry
This study was designed to determine the tumorigenicity of the AS30D HCC cell line following orthotopic injection into rat liver and preliminarily characterize the tumor model by both magnetic resonance imagin...
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Article
Secret of synapse specificity
How does the brain organize all of the information stored in memory? On the basis of a state-of-the-art imaging study of neuronal activity in real time, the answer seems to be, through specificity in space and...
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Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation
Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases1,2,3. Exogenous protein kinase activators increase...
