27 Result(s)

Article

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

Protein aggregation is a hallmark of many neurodegenerative diseases, notably Alzheimer’s and Parkinson’s disease. Parkinson’s disease is characterized by the presence of Lewy bodies, abnormal aggregates mainl...

Emma Sierecki, Nichole Giles, Quill Bowden, Mark E. Polinkovsky… in Scientific Reports (2016)

Article

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Nature 526, 564–568 (2015); doi:10.1038/nature15695 In the Methods of this Letter, ‘5,000’ should have read ‘15,000’ in the sentence: “Then, cells were again plated on a Matrigel-coated at 15,000 cells per cm2...

Minoru Takasato, Pei X. Er, Han S. Chiu, Barbara Maier, Gregory J. Baillie… in Nature (2016)

Article

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We repor...

Aleix Sala-Vila, Inmaculada Navarro-Lérida, Miguel Sánchez-Alvarez… in Scientific Reports (2016)

Article

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally a...

Albert Herms, Marta Bosch, Babu J.N. Reddy, Nicole L. Schieber… in Nature Communications (2015)

Article

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

In dispersed single beta cells the response of each cell to glucose is heterogeneous. In contrast, within an islet, cell-to-cell communication leads to glucose inducing a more homogeneous response. For example...

Jiun T. Low, Justin M. Mitchell, Oanh H. Do, Jacinda Bax, Alicia Rawlings… in Diabetologia (2013)

Article

Which Ras rides the raft? - Reply

Ian A Prior, Robert G Parton, John F Hancock in Nature Cell Biology (2001)

Article

Endosome dynamics regulated by a Rho protein

Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, ...

Carol Murphy, Rainer Saffrich, Maika Grummt, Hélèna Gournier, Vladimir Rybin… in Nature (1996)