-
Article
Adsorption of Inorganic and Organic Ions to Polycarbophil as a Means of Sustained-Release Dosage Formulation
The adsorption and desorption of drugs and inorganic ions to and from polycarbophil (PC), a polymer, were investigated to determine if PC would be a suitable carrier for sustained-release dosage formulations. ...
-
Article
Human surface electrogastrograms: AC and DC measurements
Both ac and dc abdominal electrical recordings were made on fasted and fed human subjects using a spatial array of 18 cutaneous, biopotential electrodes. Controlled skin puncture minimized cutaneous potentials...
-
Chapter
Laxatives: A Review of Their Mechanisms of Action
Laxatives are a heterogeneous group of drugs used to increase the frequency of bowel movements. They have been associated with two distinct effects on the gastrointestinal tract: a laxative-induced smooth musc...
-
Chapter
Motility: Methods for in vivo Measurements
The absorption from, and transport down the gastrointestinal tract is an important, integrated function. It is accomplished in spite of the heterogeneous motor functions of various portions of the tract; every...
-
Article
A unique distribution of laxative-induced spike potentials from the small intestine of the dog
The effects of castor oil and ricinoleic acid on small bowel electrical activity were studied in the fasted conscious dog and were compared to the effects elicited by two nonlaxative oils (triolein and oleic a...
-
Chapter
The Action of Inhalation Anesthetics on the Gastrointestinal Tract
Investigations of the action of inhalation anesthetics on the gastrointestinal tract have not kept abreast with studies on other organ systems. There are several reasons for this neglect. The unanesthetized st...
-
Article
Prolonged Administration of Atropine or Histamine in a Silicone Rubber Implant
IN the use of drugs, it is often desirable to maintain a constant blood and tissue concentration of chemical for prolonged periods. Several attempts to avoid the ‘sawtooth’ oscillations of drug-levels that acc...
