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Author Correction: Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
In the version of this Article originally published, the first name of author Guangdun Peng was spelled incorrectly as Guangdum. This has now been amended in all versions of the Article.
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Article
Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation
The morphogenetic remodelling of embryo architecture after implantation culminates in pro-amniotic cavity formation. Despite its key importance, how this transformation occurs remains unknown. Here, we apply h...
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Article
Publisher Correction: Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
In the version of this Technical Report originally published, the competing interests statement was missing. The authors declare no competing interests; this statement has now been added in all online versions...
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Article
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
Embryonic stem cells can be incorporated into the develo** embryo and its germ line, but, when cultured alone, their ability to generate embryonic structures is restricted. They can interact with trophoblast...
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Article
Open AccessAuthor Correction: Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages
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Article
Open AccessInference of differentiation time for single cell transcriptomes using cell population reference data
Single-cell RNA sequencing (scRNA-seq) is a powerful method for dissecting intercellular heterogeneity during development. Conventional trajectory analysis provides only a pseudotime of development, and often ...
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Article
Open AccessAbnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII
The paraventricular nucleus of hypothalamus plays important roles in the regulation of energy balance and fetal growth. However, the molecular mechanisms underlying its formation and function have not been cle...
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Article
Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells
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CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development
Studying the early function of essential genes is an important and challenging problem in developmental biology. Here, we established a method for rapidly inducing CRISPR-Cas9-mediated mutations in one blastom...
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Article
The genome-wide molecular regulation of mouse gastrulation embryo
The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body p...
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Article
Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq
Geo-seq combines laser capture microdissection and single-cell RNA-seq technology to enable transcriptome analysis of small quantities of cells from defined geographical locations.
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Article
Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome
PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...
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Article
Epigenetic regulation of early neural fate commitment
Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by extrinsic signals, intrinsic factors, and epigenet...
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Article
Open AccessTRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Generation of β-amyloid (Aβ) peptide in Alzheimer’s disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific...
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Article
Open AccessAF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation
AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However, AF9 function and related mechanisms in human neurode...
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Article
Open AccessThe promise of stem cells in the therapy of Alzheimer’s disease
Alzheimer’s disease (AD), a common neurodegenerative disorder associated with gradually to dramatic neuronal death, synaptic loss and dementia, is considered to be one of the most obscure and intractable brain...
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Article
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate
Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is ...
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Human Neural Development and Human Embryonic Stem Cell Neural Differentiation
Human neurodevelopment is a key process that is precisely controlled by signaling pathways, intrinsic factors and epigenetic modifications. The previous knowledge of human neurodevelopment has mainly archived ...
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Article
AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning
Bone morphogenetic protein (BMP) inhibits neural specification and induces epidermal differentiation during ectodermal patterning. However, the mechanism of this process is not well understood. Here we show th...
