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Meeteigenschappen van testen
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Open AccessMeasurement properties of instruments to assess pain in children and adolescents with cancer: a systematic review protocol
Pain in children and adolescents with cancer has been identified as an area where many healthcare professionals seek guidance. This protocol details a systematic review whose aim is to explore current knowledg...
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Open AccessValidation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study
Reports of increasing incidence rates of delirium in critically ill children are reason for concern. We evaluated the measurement properties of the pediatric delirium component (PD-scale) of the Sophia Observa...
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Open AccessIntravenous morphine versus intravenous paracetamol after cardiac surgery in neonates and infants: a study protocol for a randomized controlled trial
Morphine is worldwide the analgesic of first choice after cardiac surgery in children. Morphine has unwanted hemodynamic and respiratory side effects. Therefore, post–cardiac surgery patients may potentially b...
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Open AccessThe Rotterdam Elderly Pain Observation Scale (REPOS) is reliable and valid for non-communicative end-of-life patients
In palliative care, administration of opioids is often indispensable for pain treatment. Pain assessment may help recognize pain and guide treatment in non-communicative patients. In the Netherlands the Rotter...
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Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants
Exposure to acetaminophen and its metabolites in very-preterm infants is partly unknown. We investigated the exposure to acetaminophen and its metabolites upon 10, 15, or 20 mg/kg intravenous acetaminophen in ...
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Open AccessThermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values
Quantitative sensory testing (QST) is often used to measure children’s and adults’ detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often...
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Infant Mental Health in het ziekenhuis
Een gehechtheidsrelatie tussen ouders en hun kind begint tijdens de zwangerschap en wordt verder gevormd in contact met het kind. In dit artikel wordt beschreven wat (aanstaande) ouders bij belaste zwangerscha...
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Open AccessClinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals
This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neona...
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Open AccessLimited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure
Finding the optimal pharmacological treatment of a patent ductus arteriosus (PDA) in preterm neonates remains challenging. There is a growing interest in paracetamol as a new drug for PDA closure. In this pros...
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Open AccessMedication use during end-of-life care in a palliative care centre
Background In end-of-life care, symptoms of discomfort are mainly managed by drug therapy, the guidelines for which are mainly based on expert opinions. A few papers have inventoried drug...
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Open AccessPain in Intellectually Disabled Children: Towards Evidence-Based Pharmacotherapy?
This critical opinion article deals with the challenges of finding the most effective pharmacotherapeutic options for the management of pain in intellectually disabled children and provides recommendations for...
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Paediatric critical incident analysis: lessons learnt on analysis, recommendations and implementation
The objectives of this study were to identify causal and contributing factors of serious patient safety incidents in a paediatric university hospital, to report on ensuing recommendations and to assess the ext...
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Evidence-Based Morphine Dosing for Postoperative Neonates and Infants
From a previously validated paediatric population pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 μg/kg1.5/h, with a 50 % dose reduction in neonates with a postnatal age (PNA...
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Optimal sedation in pediatric intensive care patients: a systematic review
Sedatives administered to critically ill children should be titrated to effect, because both under- and oversedation may have negative effects. We conducted a systematic review to examine reported incidences o...
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Functional MRI pain studies in children? Yes, we (s)can!
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Skin conductance peaks could result from changes in vital parameters unrelated to pain
Pain is usually assessed by the interpretation of behavior, which can be subjective. Therefore, there is an ongoing search for more objective methods. Performance of skin conductance measurement as a pain asse...
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Open AccessReal-time registration of adverse events in Dutch hospitalized children in general pediatric units: first experiences
The objectives of this study are to describe the number and nature of adverse events occurring in general pediatric practice, to describe factors contributing to the occurrence of these adverse events, and to ...
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Open AccessScreening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS)
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Open AccessEndpoints in pediatric pain studies
Assessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analg...