317 Result(s)
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Miaomiao **n
Life Sciences
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Article
Open AccessPhylogeny and expression patterns of ERF genes that are potential reproductive inducers in hybrid larch
Larch is an important component of northern forests and a major cultivated tree species in restoration of forest cover using improved seed material. In recent years, the continuous low seed production has seve...
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Global Environmental Change Shifts Ecological Stoichiometry Coupling Between Plant and Soil in Early-Stage Invasions
Extensive research has been conducted on the ecological stoichiometry of plants and soils. However, the relationship between plants and soil stoichiometry under the global environmental change is not fully und...
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Open AccessPhenolic compounds induce ferroptosis-like death by promoting hydroxyl radical generation in the Fenton reaction
Phenolic compounds are industrially versatile chemicals, also the most ubiquitous pollutants. Recently, biosynthesis and biodegradation of phenols has attracted increasing attention, while phenols’ toxicity is...
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Thiopseudomonas acetoxidans sp. nov., an aerobic acetic and butyric acids oxidizer isolated from anaerobic fermentation liquid of food waste
A Gram-stain-negative, oxidase-negative, rod-shaped, motile, facultatively anaerobic bacterial strain, designated as CY1220T, was isolated from an anaerobic fermentation liquid of food waste treatment plant. Phyl...
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Open AccessSingle-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis
Cervical cancer (CC) is a common gynecological malignancy. Despite the current screening methods have been proved effectively and significantly decreased CC morbidity and mortality, deficiencies still exist. S...
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Open AccessSynergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
Though (1S, 3R)-RSL3 has been used widely in basic research as a small molecular inducer of ferroptosis, the toxicity on normal cells and poor pharmacokinetic properties of RSL3 limited its clinical applicatio...
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Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes
Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity, posing a serious threat to pharmaceutical industries and patients’ lives. However, mitochondrial toxicity testing ...
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The effect of metformin combined with liraglutide on gut microbiota of Chinese patients with type 2 diabetes
Metformin (MET) is a first-line therapy for type-2 diabetes mellitus (T2DM). Liraglutide (LRG) is a glucagon-like peptide-1 receptor agonist used as a second-line therapy in combination with MET.
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Open AccessExogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3β axis in non-small cell lung cancer
The gas therapy is drawing increasing attention in the treatment of many diseases including cancer. As one of gas signaling molecules, carbon monoxide (CO) has been proved to exert anti-cancer effects via trigger...
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Screening and identification of photoresponse factors in kiwifruit (Actinidia arguta) development
Light is essential for kiwifruit development, in which photoresponse factors contributes greatly to the quality formation. ‘Light sensitive hypocotyls, also known as light-dependent short hypocotyls’ (LSH) gene f...
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Open AccessCommunity composition of phytopathogenic fungi significantly influences ectomycorrhizal fungal communities during subtropical forest succession
Ectomycorrhizal fungi (EMF) can form symbiotic relationships with plants, aiding in plant growth by providing access to nutrients and defense against phytopathogenic fungi. In this context, factors such as pla...
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Open AccessTaWRKY31, a novel WRKY transcription factor in wheat, participates in regulation of plant drought stress tolerance
Wheat, a crucial food crop in China, is highly vulnerable to drought stress throughout its growth and development. WRKY transcription factors (TFs), being one of the largest families of TFs, play a vital role ...
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PTBP1 as a potential regulator of disease
Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PT...
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Open AccessEmerging role of mesenchymal stromal cells in gynecologic cancer therapy
Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomodulatory, and angiogenic functions. More recently, discovered with the tumor tropism, MS...
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Fluorofenidone Attenuates Renal Interstitial Fibrosis by Enhancing Autophagy and Retaining Mitochondrial Function
Fluorofenidone (AKF-PD) is a novel pyridone agent and has potent anti-NLRP3 inflammasome and anti-fibrotic activities. However, the mechanisms underlying its pharmacological actions are not fully understood.
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Soil properties and plant diversity co-regulate ecosystem multifunctionality of subalpine primary dark coniferous forest on the eastern Qinghai-Tibetan Plateau
Plants and soils are key factors in maintaining ecosystem multifunctionality (EMF). Yet, it remains unclear how climate factors regulate the EMF through soil properties and plant diversity of different plant f...
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Open AccessTime series single-cell transcriptional atlases reveal cell fate differentiation driven by light in Arabidopsis seedlings
Light serves as the energy source for plants as well as a signal for growth and development during their whole life cycle. Seedling de-etiolation is the most dramatic manifestation of light-regulated plant dev...
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Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells
Hyperhomocysteinemia (HHcy) plays a salient role in male infertility. However, whether HHcy interferes with testosterone production remains inconclusive. Here, we reported a lower serum testosterone level in H...
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The phase variation between wrinkly and smooth colony phenotype affects the virulence of Vibrio parahaemolyticus
Vibrio parahaemolyticus, the causative agent of seafood-associated gastroenteritis, undergoes wrinkly and smooth colony switching on the plate. The wrinkly spreader grew faster, had stronger motility and biofilm ...
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Open AccessADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts
Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is characterized by aberrant myofibroblast activation and patholo...
