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Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch
B lymphocytes may switch from producing an immunoglobulin heavy chain of the μ class to that of the γ, ε or α class1–4. To maintain the specificity, the new heavy chain must keep the original variable (V) region;...
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Immunoglobulin heavy chain binding protein
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain1. In the Abelson virus transformed line 18-81, which is representative of the pre...
