65 Result(s)

Article

Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis

The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adeq...

Marcel Levi in Critical Care (2013)

Article

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2012)

Article

Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh… in BMC Pulmonary Medicine (2012)

Article

Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations

Data from interventional trials of systemic anticoagulation for sepsis inconsistently suggest beneficial effects in case of acute lung injury (ALI). Severe systemic bleeding due to anticoagulation may have off...

Pieter R Tuinman, Barry Dixon, Marcel Levi, Nicole P Juffermans… in Critical Care (2012)

Article

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activati...

Marcel Levi, Tom van der Poll, Marcus Schultz in Seminars in Immunopathology (2012)

Article

Acute Stress Elicited by Bungee Jum** Suppresses Human Innate Immunity

Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain...

David J. van Westerloo, Goda Choi, Ester C. Löwenberg, Jasper Truijen… in Molecular Medicine (2011)

Article

Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study

Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...

Pieter R Tuinman, Alexander P Vlaar, Alexander D Cornet, Jorrit J Hofstra… in Critical Care (2011)

Article

Treatment with recombinant human activated protein C: one size does not fit all

Protein C plays an important role in the coagulopathy associated with sepsis and probably also in the pathogenesis of sepsis-induced organ dysfunction. Plasma levels of protein C strongly correlate with clinic...

Marcel Levi in Critical Care (2011)

Article

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2010)

Article

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema

We published the Canadian 2003 International Consensus Algorithm for the Diagnosis, Therapy, and Management of Hereditary Angioedema (HAE; C1 inhibitor [C1-INH] deficiency) and updated this as Hereditary angio...

Tom Bowen, Marco Cicardi, Henriette Farkas… in Allergy, Asthma & Clinical Immunology (2010)

Article

Adequate thromboprophylaxis in critically ill patients

Venous thromboembolism is a relatively frequently occurring complication in critically ill patients admitted to the ICU despite prophylactic treatment with subcutaneous low molecular weight heparin. Several st...

Marcel Levi in Critical Care (2010)

Article

Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats

Disturbed alveolar fibrin turnover is a cardinal feature of severe pneumonia. Clinical studies suggest that natural inhibitors of coagulation exert lung-protective effects via anticoagulant and possibly also a...

Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar… in Critical Care (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

The safety of using heparin concomitantly with drotrecogin alfa (activated) {DrotAA} was explored in the XPRESS study. No heparin effect on mortality was observed. Safety results from that study are explored i...

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

Improvement in the regulation of the vitamin K antagonist acenocoumarol after a standard initial dose regimen: prospective validation of a prescription model

Background In a retrospective study we have developed a model which determines the dose of acenocoumarol based on the age of the patient and on the first INR obtained after a standard ini...

Johanna H. H. Van Geest-Daalderop… in Journal of Thrombosis and Thrombolysis (2009)

Article

The inflammation–coagulation axis as an important intermediate pathway in acute lung injury

Markers of inflammation, coagulation, and fibrinolysis predict an adverse outcome in patients with sepsis. These markers also seem predictive of an adverse outcome in patients with localized infection and infl...

Marcel Levi, Marcus Schultz in Critical Care (2008)