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Chapter
Structure-Function Relationships
Understanding, in molecular terms, the ways in which extracellular signals are transduced across the cell membrane so as to modify key intracellular metabolic processes ultimately requires that the various ele...
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Chapter
Structure and Function of the Adrenergic Receptor Family
The interaction of hormones and drugs with their respective targets has been widely studied with the hope that a better understanding of the molecular basis of their actions would provide insights not only int...
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Article
D2 dopamine receptors in the human retina: Cloning of cDNA and localization of mRNA
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We have obtained a cDNA clone encoding a human retinal D2 dopamine receptor.
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Article
Cloning and expression of a functional serotonin transporter from rat brain
SELECTIVE antagonism of serotonin (5-hydroxytryptamine, 5HT) and noradrenaline transport by antidepressants is a key element in the 'amine' hypothesis of affective disorders1. Uptake2,3 and/or transport sites4,5 ...
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Chapter
Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins
A remarkably diverse array of biologically active substances elicit their actions by interacting with Cell surface receptors which are coupled via guanine nucleotide regulatory proteins (G-proteins) to specifi...
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Article
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
RHODOPSIN kinase1 and β-adrenergic receptor kinase (β ARK)2 are related members of a serine/threonine kinase family that specifically initiate deactivation of G-protein-coupled receptors. After stimulus-mediated ...
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Article
Dopamine receptors status after unilateral nigral 6-OHDA lesion
The physiological effects of dopamine (DA) are mediated by several distinct receptor subtypes. The effects of unilateral nigral 6-hydroxydopamine (6-OHDA) lesions on DA receptors were investigated by receptor ...
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Article
The chimaeras speak again
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Article
Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion
Congenital myoclonus is a widespread neurologic disorder characterized by hyperexcitability, muscular spasticity and myoclonus associated with marked reduction in neural glycine binding sites. The recessive mo...
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Chapter
Receptor-G Protein-Effector Coupling: Coding and Regulation of the Signal Transduction Process
Regulation of G protein mediated signal transduction is thought to occur primarily as the result of the occupancy of a receptor by the appropriate agonist. There is much regulation of this process, however, wh...
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Article
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels. In homozygote mice, dopamine ...
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Chapter
Interactions of Dopamine Receptors with G Proteins
Dopamine is an important neurotransmitter, playing roles in motor control, emotion and affect, neuroendocrine regulation, and regulation of sodium uptake in the kidney, among other functions. The receptors for...
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Article
Cocaine self-administration in dopamine-transporter knockout mice
The plasma membrane dopamine transporter (DAT) is responsible for clearing dopamine from the synapse. Cocaine blockade of DAT leads to increased extracellular dopamine, an effect widely considered to be the pr...
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Article
Loss of autoreceptor functions in mice lacking the dopamine transporter
Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a compo...
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Article
Application of microdialysis and voltammetry to assess dopamine functions in genetically altered
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Chapter
Involvement of Dopamine Transporters in Psychiatric Disorders
The plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) are key regulators of dopamine neurotransmission. DAT acts to terminate the actions of dopamine by rapidly removin...
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Article
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimu...
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Article
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence. The development of opiate tolerance occurs on continued use of the drug such that the amount of drug required to eli...
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Protocol
Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice
One of the most valuable methods for understanding the function of a particular protein is the generation of animals that have had the gene encoding for the protein of interest disrupted, commonly known as a “...
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Chapter
G Proteins and G Protein-Coupled Receptors
Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of t...
