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M. **gliang
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Open AccessIdentification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD through integrative analysis of...
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Open AccessImplementation of social needs screening for minoritized patients newly diagnosed with breast cancer: a mixed methods evaluation in a pragmatic patient navigation trial
Social needs inhibit receipt of timely medical care. Social needs screening is a vital part of comprehensive cancer care, and patient navigators are well-positioned to screen for and address social needs. This...
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Open AccessIdentification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring their connection with disease status. Retinal cross-sections f...
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Open AccessDissecting the components of error in analogue report tasks
Over the last two decades, the analogue report task has become a standard method for measuring the fidelity of visual representations across research domains including perception, attention, and memory. Despit...
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Open AccessExtremozymes and compatible solute production potential of halophilic and halotolerant bacteria isolated from crop rhizospheric soils of Southwest Saurashtra Gujarat
Halophiles are one of the classes of extremophilic microorganisms that can flourish in environments with very high salt concentrations. In this study, fifteen bacterial strains isolated from various crop rhizo...
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Open AccessHierarchically porous and single Zn atom-embedded carbon molecular sieves for H2 separations
Hierarchically porous materials containing sub-nm ultramicropores with molecular sieving abilities and microcavities with high gas diffusivity may realize energy-efficient membranes for gas separations. Howeve...
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Open AccessDie Novellierung des § 64 StGB – Vorschläge zur Anwendung aus rechts- und erfahrungswissenschaftlicher Sicht
Die Novellierung des § 64 des Strafgesetzbuches (StGB) ist am 01.10.2023 in Kraft getreten. Der vorliegende Beitrag beschäftigt sich mit den rechts- und erfahrungswissenschaftlichen Voraussetzungen der Anwendu...
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Open AccessGenetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models
Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequ...
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Open AccessA data science roadmap for open science organizations engaged in early-stage drug discovery
The Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, bel...
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Open AccessGlobal biogeographic regions for ants have complex relationships with those for plants and tetrapods
On a global scale, biodiversity is geographically structured into regions of biotic similarity. Delineating these regions has been mostly targeted for tetrapods and plants, but those for hyperdiverse groups su...
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Open AccessAn activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-o...
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Open AccessSingle-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell glucotoxicity and subsequently type 2 diabetes. In this study, we explored the...
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Open AccessCorrection: Impact of non-pharmaceutical interventions during COVID-19 on future influenza trends in Mainland China
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Open AccessInsights into the seismogenic structures of the arc-continent convergent plate boundary in eastern Taiwan
The doubly vergent orogen in Taiwan is a relatively young and active arc-continent collision caused by the convergence of Eurasian and Philippine Sea Plates occurring along a complicated seismogenic plate boun...
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Open AccessLate Paleocene paleoclimate recorded in fluid inclusion of halite in Subei basin, East China
Salt deposits are indicative of relatively extreme climate events. However, due to insufficient independent temperature proxies, paleotemperature records obtained from salt deposition are still lack. The Paleo...
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Open AccessAndrogen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy
Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90...
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Open AccessSHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis
Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that...
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Open AccessRenal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure
The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hyperten...
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Open AccessInfluenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Epidemiological studies link exposure to viral infection during pregnancy, including influenza A virus (IAV) infection, with increased incidence of neurodevelopmental disorders (NDDs) in offspring. Models of m...
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Open AccessReversible two-way tuning of thermal conductivity in an end-linked star-shaped thermoset
Polymeric thermal switches that can reversibly tune and significantly enhance their thermal conductivities are desirable for diverse applications in electronics, aerospace, automotives, and medicine; however, ...
