101 Result(s)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator ...

Lihui Lu, Jianwei Wang, Fang Fang, Ailian Guo, Shuting Jiang… in Cell Death & Disease (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...

Yu-Fei Cao, Lei **e, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi… in Cell Death & Differentiation (2023)

Article

Non-invasive plasma testing for CD274 UTR structural variations by next-generation sequencing in cancer

Immunotherapy is now the main choice of systemic therapy for many cancer patients, while current biomarkers for tumor immunotherapy may be limited by the accessibility of patient tumor tissue or tumor neoplast...

Wenjuan Zhang, Jian Cao, Ke Liu, Ziwei Qu, Ying Zheng, Jun Yu… in Cell Death Discovery (2023)

Article

The mutation rate of rpoB gene showed an upward trend with the increase of MIRU10, MIRU39 and QUB4156 repetitive number

Mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) is a frequently used ty** method for identifying the Bei**g genotype of Mycobacterium tuberculosis (Mtb), which is easily tr...

Fan Su, Lei Cao, **a Ren, Jian Hu, Grace Tavengana, Huan Wu, Yumei Zhou… in BMC Genomics (2023)

Article

FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy

Sustained cardiac hypertrophy often develops maladaptive myocardial remodeling, and eventually progresses to heart failure and sudden death. Therefore, maladaptive hypertrophy is considered as a critical thera...

Teng Sun, Yu Han, Jia-Lei Li, **ang-Ying Jiao, Lin Zuo, ** Wang… in Cell & Bioscience (2022)

Article

Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid malignancy in the “L-group” histiocytosis. Mitogen-activated protein kinase (MAPK) pathway activating mutations are detectable in nearly all LCH l...

Xue-min Gao, Jian Li, **n-xin Cao in Cell Communication and Signaling (2022)

Article

RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling

Breast cancer is the most common malignancy in women on a global scale. It can generally be divided into four main categories, of which estrogen receptor ER-positive breast cancer accounts for most breast canc...

Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, **n Li… in Cell Death & Disease (2022)

Article

Targeting papain-like protease for broad-spectrum coronavirus inhibition

The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics. Drugging the multi-f...

Shuofeng Yuan, **aopan Gao, Kaiming Tang, Jian-Piao Cai, Menglong Hu… in Protein & Cell (2022)

Article

Fungal diversity notes 1512–1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this stu...

Ruvishika S. Jayawardena, Kevin D. Hyde, Song Wang, Ya-Ru Sun… in Fungal Diversity (2022)

Article

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma

Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...

Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao… in Cell & Bioscience (2022)

Article

Complete genome sequencing and investigation on the fiber-degrading potential of Bacillus amyloliquefaciens strain TL106 from the tibetan pig

Cellulolytic microorganisms are considered a key player in the degradation of feed fiber. These microorganisms can be isolated from various resources, such as animal gut, plant surfaces, soil and oceans. A new...

Zhenda Shang, Suozhu Liu, Yanzhen Duan, Chengling Bao, Jian Wang… in BMC Microbiology (2022)

Article

Author Correction: Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors

Qian Xu, Chunyan Wu, Qi Zhu, Renyuan Gao, Jianquan Lu… in Nature Aging (2022)

Article

Author Correction: Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth

Jiang-Sha Zhao, Shuo Shi, Hai-Yan Qu, Zuzana Keckesova, Zi-Jian Cao… in Nature Metabolism (2022)

Article

Disruption of three polyamine uptake transporter genes in rice by CRISPR/Cas9 gene editing confers tolerance to herbicide paraquat

Weeds are a major biotic constraint that can cause dramatic crop production losses. Herbicide technology has been widely used by farmers as the most cost-effective weed control measure, and development of new ...

Yu-Shu Lyu, Li-Miao Cao, Wen-Qian Huang, Jian-**ang Liu, Hai-** Lu in aBIOTECH (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

Rebuilding hippocampus neural circuit with hADSC-derived neuron cells for treating ischemic stroke

Human adipose-derived stem cells (hADSCs) have been demonstrated to be a promising autologous stem cell source for treating various neuronal diseases. Our study indicated that hADSCs could be induced into neur...

Jian Wang, Rui Hao, Tianfang Jiang, Xuanxuan Guo, Fei Zhou, Limei Cao… in Cell & Bioscience (2022)

Article

BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma

Neuroblastoma (NB) is a common extracranial malignancy with high mortality in children. Recently, super-enhancers (SEs) have been reported to play a critical role in the tumorigenesis and development of NB via...

Yan-Ling Chen, **ao-Lu Li, Gen Li, Yan-Fang Tao, Ran Zhuo, Hai-Bo Cao… in Cell & Bioscience (2022)

Article

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PT...

Yunyun **, Qianqian Liu, Peng Chen, Siyuan Zhao, Wenhao Jiang… in Cell Discovery (2022)