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Article
Open AccessSLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway
Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In thi...
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Article
Open AccessElimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis
Cancer side-population (SP) represents a sub-population of stem-like cancer cells that have an important role in drug resistance due to their high expression of the ATP-binding cassette transporter ABCG2 invol...
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Article
Open AccessH19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer ...
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Article
Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 The authors apologized for the mistake of mis-labeling the affiliation for Dr Stuart H Orkin, his aff...
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Article
Erratum: A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
Correction to: Cell Research (2017) 27:386–401. doi:10.1038/cr.2017.17; published online on 27 January 2017 During web production, there is an error in the web site for the labeling of Dr Bin Zhou, his affilia...
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Article
A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations
Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require fur...
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Article
Open AccessIRF4 is a novel mediator for neuronal survival in ischaemic stroke
Neuroprotection following ischaemic stroke is driven by the interplay between regulatory transcription factors and endogenous protective factors. IRF4, a member of the interferon regulatory factor (IRF) family...
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Article
A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population
Homocysteine is an independent risk factor for various cardiovascular diseases. There are two ways to remove homocysteine from embryonic cardiac cells: remethylation to form methionine or transsulfuration to f...
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Article
Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601
The virulence-attenuated Leptospira interrogans serovar Lai strain IPAV was derived by prolonged laboratory passage from a highly virulent ancestral strain isolated in China. We studied the genetic variations of ...
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Article
Transplantation of marrow stromal cells to rescue retinal cells in SI-induced retinal degeneration in rats