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Article
Einflüsse von Bradykinin auf die systemische und die pulmonale Hämodynamik am Menschen
In our studies we investigated the vasodepressor effects of bradykinin in vivo in normotensive and hypertensive subjects. Bradykinin was injected intravenously and intraarterially (40–6050 pM/kg) respectively ...
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Article
Interference of different ACE-inhibitors with the diuretic action of furosemide and hydrochlorothiazide
In healthy volunteers the acute effect of furosemide (40 mg i.v.) and hydrochlorothiazide (100 mg p.o.) on diuresis, natriuresis and renal kallikrein and kinin excretion was investigated. Furosemide stimulated...
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Chapter and Conference Paper
Effect of Nifedipine on Plasma ANP-Levels and Pulmonary Hemodynamics in Patients with Pulmonary Hypertension During Exercise
Calcium ions seem to be intimately involved in the secretion of atrial natriuretic peptide: in isolated atrial tissue, ANP release was stimulated by the addition of calcium and calcium agonists. In contrast, c...
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Chapter and Conference Paper
Diagnostic Value of Plasma Levels of Atrial Natriuretic Peptide (ANP) in Different Cardiac Diseases
Several authors found a correlation of plasma levels of ANP with the impairment of cardiac function [1–3, 5–8]. In order to assess its diagnostic value in a clinical routine setting we measured plasma levels o...
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Article
Plasma levels of atrial natriuretic peptide are raised in essential hypertension during low and high sodium intake
Plasma levels of α-human atrial natriuretic peptide (hANP) were measured in 17 patients with primary hypertension (11 females, 6 males, aged 22–61; blood pressure systolic 154±7 mmHg, diastolic 92±4 mmHg) and ...
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Article
Sodium loading raises urinary cortisol in man
It has been suggested that cortisol secretion is modified by sodium intake. We therefore studied the pituitary-adrenal axis by measuring diurnal rhythms of ACTH and cortisol levels in serum of 10 normal contro...
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Chapter and Conference Paper
Critical Evaluation of Basic Mechanisms of Primary Hypertension
The round-table discussion was held to evaluate critically the significance of the pathogenetic mechanisms presented during the preceding session. It afforded opportunity to identify areas of consensus or cont...
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Article
Cardiovascular and adrenal sensitivity to angiotensin II in essential hypertension
Regulation of aldosterone secretion by sodium chloride is impaired in a group of essential hypertensives: high-salt diet fails to suppress aldosterone in these patients despite low renin values. The mechanism ...
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Article
The renal kallikrein-kinin system in spontaneously hypertensive rats
In male spontaneously hypertensive rats (SHRSP) of the stroke prone strain (Okamoto) and in normotensive Wistar-Kyoto rats (WKY) urinary kallikrein excretion was investigated at different age and at drug-induc...
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Chapter
The Influence of the Kallikrein-Kinin System in the Development of the Pancreatic Shock
Kallikrein and other kininogenases like trypsin and plasmin release kinins by limited proteolysis from high (HMWK) — and low molecular weight kininogen (LMWK). The kinins are vasoactive peptides with fairly un...
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Chapter and Conference Paper
Der Einfluß endogen freigesetzter Kinine auf den Verlauf der experimentellen akuten hämorrhagischen Pankreatitis
Den Kininen wird bei der Entwicklung des pankreatogenen Schocks eine entscheidende Bedeutung beigemessen.
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Article
Relationship between the renal kallikrein activity and the urinary excretion of kallikrein in rats
Adrenalectomy reduces, and sodium depletion increases, both the daily urinary excretion of kallikrein and the kallikrein activity in the renal cortex. These 2 variables were found to correlate significantly in...
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Chapter and Conference Paper
Hypertonie
Über die Reaktion des sympathikoadrenalen Systems im psychischen Streß finden sich zahlreiche, jedoch sehr unterschiedliche Resultate. Messungen der Plasmakatecholamine ergaben, daß Adrenalin selektiv anstieg ...
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Chapter and Conference Paper
Pathophysiologic Basis of Antihypertensive Therapy in Man
Regarding different theories on the pathogenesis of arterial hypertension, for instance, Page’s mosaic theory, the concept of Helmer, or Guyton’s analysis of circulation [16], it becomes obvious that arterial ...
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Article
Increased kallikrein excretion in spontaneously hypertensive rats and its inhibition by 6-hydroxydopamine
Urinary kallikrein excretion was studied in young, stroke-prone, spontaneously hypertensive rats (spSHR). Seven-week-old spSHR were found to excrete more kallikrein into the urine than normotensive Wistar Kyot...
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Article
Ureteral contractions induced by rat urine in vitro: Probable involvement of renal kallikrein
Rat urine, even at a 1∶10 final dilution in Tyrode's solution, stimulates contraction of the ureteral musculature in vitro. This effect can be ascribed to the presence of kallikrein or a kallikrein-like enzyme...
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Article
Evidence for a subgroup of essential hypertensives with non-suppressible excretion of aldosterone during sodium loading
Bei Patienten mit essentieller Hypertonie Grad I und II fand sich unter Salzbelastungsbedingungen (Natrium-Exkretion über 175 mval·d−1) eine bimodale Verteilung der Aldosteron-Exkretion, aufgrund welcher zwei Pat...
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Chapter and Conference Paper
Urinary Kallikrein Activity in Rats with Renovascular Hypertension
Renovascular hypertension in rats was induced by two different methods, the two kidney, one clip renal hypertension and the ligature of the aorta between the origins of both renal arteries. After unilateral re...
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Chapter and Conference Paper
Disturbed Regulation of Aldosterone and Sodium Excretion in a Subgroup of Essential Hypertensives
The phenomenon of low plasma renin activity in approximately 25% of essential hypertensives has initiated a great deal of interest into investigating signs of mineralocorticoid excesss in these patients. The r...
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Article
Natrium-Kalium-Adenosintriphosphatase-Aktivität in Erythrozytenghosts von Patienten mit essentieller Hypertonie
Increased sodium concentration and high influx of Na22 are reported in erythrocytes of patients with essential hypertension. It was speculated, that these findings are due to a disturbed transport for sodium acro...
